{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang H"],"funding":["Science and Technology Department of Henan Province","National Natural Science Foundation of China","Education Department of Henan Province"],"pagination":["6511"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12910028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Osteoporosis is associated with cardiovascular disease, but the relationship between bone mineral density (BMD) and cardiac structure and function remains incompletely understood. This cross-sectional study analyzed baseline data from 1233 participants (median age 60 years; 59% female) in the Osteoarthritis and Cardiovascular Health Cohort. BMD was categorized as normal (T-score ≥ - 1.0, n = 364), osteopenia (- 2.5 < T-score < - 1.0, n = 404), or osteoporosis (T-score ≤ - 2.5, n = 465). Cardiac parameters were measured via echocardiography. Multivariable linear regression adjusted for age, sex, and cardiovascular risk factors. Osteoporosis was associated with higher LAVI (median: 29 vs. 26 mL/m<sup>2</sup>, P < 0.001) and RWT (0.38 vs. 0.37, P = 0.047) compared to normal BMD. After adjustm"],"journal":["Scientific reports"],"pubmed_title":["Osteoporosis and cardiac remodeling in middle-aged and older adults: a cross-sectional study."],"pmcid":["PMC12910028"],"funding_grant_id":["232300420069, 232102310231, 232300420289","22B320003","81803318"],"pubmed_authors":["Wang N","Wang Q","Cai J","Wang H","Bai J","Liu D","Xie Q","He B","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Osteoporosis and cardiac remodeling in middle-aged and older adults: a cross-sectional study.","description":"Osteoporosis is associated with cardiovascular disease, but the relationship between bone mineral density (BMD) and cardiac structure and function remains incompletely understood. This cross-sectional study analyzed baseline data from 1233 participants (median age 60 years; 59% female) in the Osteoarthritis and Cardiovascular Health Cohort. BMD was categorized as normal (T-score ≥ - 1.0, n = 364), osteopenia (- 2.5 < T-score < - 1.0, n = 404), or osteoporosis (T-score ≤ - 2.5, n = 465). Cardiac parameters were measured via echocardiography. Multivariable linear regression adjusted for age, sex, and cardiovascular risk factors. Osteoporosis was associated with higher LAVI (median: 29 vs. 26 mL/m<sup>2</sup>, P < 0.001) and RWT (0.38 vs. 0.37, P = 0.047) compared to normal BMD. After adjustm","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T00:32:38.685Z","creation":"2026-07-09T13:09:54.62Z"},"accession":"S-EPMC12910028","cross_references":{"pubmed":["41606044"],"doi":["10.1038/s41598-026-37360-x"]}}