biostudies-literatureWang HScience and Technology Department of Henan ProvinceNational Natural Science Foundation of ChinaEducation Department of Henan Province6511https://www.ebi.ac.uk/biostudies/studies/S-EPMC12910028biostudies-literatureUnknown16(1)Osteoporosis is associated with cardiovascular disease, but the relationship between bone mineral density (BMD) and cardiac structure and function remains incompletely understood. This cross-sectional study analyzed baseline data from 1233 participants (median age 60 years; 59% female) in the Osteoarthritis and Cardiovascular Health Cohort. BMD was categorized as normal (T-score ≥ - 1.0, n = 364), osteopenia (- 2.5 < T-score < - 1.0, n = 404), or osteoporosis (T-score ≤ - 2.5, n = 465). Cardiac parameters were measured via echocardiography. Multivariable linear regression adjusted for age, sex, and cardiovascular risk factors. Osteoporosis was associated with higher LAVI (median: 29 vs. 26 mL/m², P < 0.001) and RWT (0.38 vs. 0.37, P = 0.047) compared to normal BMD. After adjustmScientific reportsOsteoporosis and cardiac remodeling in middle-aged and older adults: a cross-sectional study.PMC12910028232300420069, 232102310231, 23230042028922B32000381803318Wang NWang QCai JWang HBai JLiu DXie QHe BWang JfalseOsteoporosis and cardiac remodeling in middle-aged and older adults: a cross-sectional study.Osteoporosis is associated with cardiovascular disease, but the relationship between bone mineral density (BMD) and cardiac structure and function remains incompletely understood. This cross-sectional study analyzed baseline data from 1233 participants (median age 60 years; 59% female) in the Osteoarthritis and Cardiovascular Health Cohort. BMD was categorized as normal (T-score ≥ - 1.0, n = 364), osteopenia (- 2.5 < T-score < - 1.0, n = 404), or osteoporosis (T-score ≤ - 2.5, n = 465). Cardiac parameters were measured via echocardiography. Multivariable linear regression adjusted for age, sex, and cardiovascular risk factors. Osteoporosis was associated with higher LAVI (median: 29 vs. 26 mL/m², P < 0.001) and RWT (0.38 vs. 0.37, P = 0.047) compared to normal BMD. After adjustm2026-01-01T00:00:00Z2026 Jan2026-07-16T00:32:38.685Z2026-07-09T13:09:54.62ZS-EPMC129100284160604410.1038/s41598-026-37360-x