{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao H"],"funding":["Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders","Innovation and Technology Fund for State Key Laboratory","Guangdong Provincial Fund for Basic and Applied Basic Research","National Medical Research Council Singapore Translational Research Investigator Award","Research Grants Council of Hong Kong General Research Fund","Areas of Excellence Scheme of the University Grants Committee","InnoHK Initiative of the Innovation and Technology Commission of the HKSAR Government","SIAT-HKUST Joint Laboratory for Brain Science","JSPS Grant-in-Aid for Scientific Research","AMED","Japan Agency for Medical Research and Development","Research Grants Council of Hong Kong Collaborative Research Fund","Research Grants Council of Hong Kong Theme-Based Research Scheme","Fidelity Foundation"],"pagination":["e71219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12910251"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(2)"],"pubmed_abstract":["<h4>Introduction</h4>Genome-wide association studies have identified numerous Alzheimer's disease (AD) susceptibility loci in European populations. However, the genetic architecture of AD in non-European populations remains underinvestigated.<h4>Methods</h4>We performed a genetic association study in East Asians (N = 8514) to validate known AD loci and identify new susceptibility loci.<h4>Results</h4>We identified LILRB2-LILRB5 as an AD susceptibility locus with ethnic-specific effects between Europeans and East Asians. The lead variant, rs587709-T, was associated with decreased AD risk and increased LILRB5 expression in Europeans. Conversely, in East Asians, the same allele was associated with increased AD risk and increased LILRB2 expression. Furthermore, genome-wide analysis identified "],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population."],"pmcid":["PMC12910251"],"funding_grant_id":["2019B1515130004","HKUST16102824","JP25dk0207060","HKUST16104624","AoE/M-604/16","ITCPD/17-9","FIF20RD01","HKUST16103122","JLFS/M-604/24","T13-605/18W","C6027-19GF","25K02262","2023B1212120004","MOH-000707-00"],"pubmed_authors":["Japanese Alzheimer's Disease Neuroimaging Initiative","Chan ALT","Cao H","Kikuchi M","Hardy J","Wong HY","Shoai M","Miyashita A","Kwok TCY","Mok VCT","Fu AKY","Cheng EYL","Chen Y","Chong JR","Ip FCF","Zheng Z","Ikeuchi T","Lo RMN","Chen C","Zhou X","Alzheimer's Disease Neuroimaging Initiative","Lam LCW","Mok KY","Ip NY","Wong BWY"],"additional_accession":[]},"is_claimable":false,"name":"Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population.","description":"<h4>Introduction</h4>Genome-wide association studies have identified numerous Alzheimer's disease (AD) susceptibility loci in European populations. However, the genetic architecture of AD in non-European populations remains underinvestigated.<h4>Methods</h4>We performed a genetic association study in East Asians (N = 8514) to validate known AD loci and identify new susceptibility loci.<h4>Results</h4>We identified LILRB2-LILRB5 as an AD susceptibility locus with ethnic-specific effects between Europeans and East Asians. The lead variant, rs587709-T, was associated with decreased AD risk and increased LILRB5 expression in Europeans. Conversely, in East Asians, the same allele was associated with increased AD risk and increased LILRB2 expression. Furthermore, genome-wide analysis identified ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T05:02:15.482Z","creation":"2026-07-09T10:36:35.749Z"},"accession":"S-EPMC12910251","cross_references":{"pubmed":["41700061"],"doi":["10.1002/alz.71219"]}}