{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["de Moura HL"],"funding":["NIBIB NIH HHS","NIAMS NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Early detection of knee osteoarthritis (OA) is important. Spin-lattice relaxation in the rotating frame (T<sub>1ρ</sub>) mapping is sensitive to early cartilage changes, but the mono-exponential (ME) model may be limited. Multi-component models can capture more tissue complexity, but their diagnostic advantage has not been validated.<h4>Purpose</h4>To evaluate if stretched- (SE) and bi-exponential (BE) T<sub>1ρ</sub> models can improve early knee OA detection over the ME model.<h4>Study type</h4>Case-control study.<h4>Population</h4>Twenty-six healthy subjects (mean age 51.5) and 26 early knee OA patients (mean age 61.8).<h4>Field strength/sequence</h4>T<sub>1ρ</sub>-prepared Turbo FLASH sequence at 3 T field strength.<h4>Assessment</h4>T<sub>1ρ</sub> parameters from thr"],"journal":["Journal of magnetic resonance imaging : JMRI"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12910345"],"repository":["biostudies-literature"],"pubmed_title":["Detection of Early Knee Osteoarthritis Using Multi-Component T&lt;sub&gt;1ρ&lt;/sub&gt; Mapping."],"pmcid":["PMC12910345"],"funding_grant_id":["R01-AR076985","R01 AR076328","R01 AR078308","P41 EB017183","R01-AR076328","R01-AR078308","R01 AR076985"],"pubmed_authors":["Samuels J","de Moura HL","Regatte RR","Singh D","Zibetti MVW","Monga A"],"additional_accession":[]},"is_claimable":false,"name":"Detection of Early Knee Osteoarthritis Using Multi-Component T&lt;sub&gt;1ρ&lt;/sub&gt; Mapping.","description":"<h4>Background</h4>Early detection of knee osteoarthritis (OA) is important. Spin-lattice relaxation in the rotating frame (T<sub>1ρ</sub>) mapping is sensitive to early cartilage changes, but the mono-exponential (ME) model may be limited. Multi-component models can capture more tissue complexity, but their diagnostic advantage has not been validated.<h4>Purpose</h4>To evaluate if stretched- (SE) and bi-exponential (BE) T<sub>1ρ</sub> models can improve early knee OA detection over the ME model.<h4>Study type</h4>Case-control study.<h4>Population</h4>Twenty-six healthy subjects (mean age 51.5) and 26 early knee OA patients (mean age 61.8).<h4>Field strength/sequence</h4>T<sub>1ρ</sub>-prepared Turbo FLASH sequence at 3 T field strength.<h4>Assessment</h4>T<sub>1ρ</sub> parameters from thr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-16T03:17:03.904Z","creation":"2026-07-09T10:31:12.787Z"},"accession":"S-EPMC12910345","cross_references":{"pubmed":["41473939"],"doi":["10.1002/jmri.70224"]}}