biostudies-literatureUnknownde Moura HLNIBIB NIH HHSNIAMS NIH HHS<h4>Background</h4>Early detection of knee osteoarthritis (OA) is important. Spin-lattice relaxation in the rotating frame (T_1ρ) mapping is sensitive to early cartilage changes, but the mono-exponential (ME) model may be limited. Multi-component models can capture more tissue complexity, but their diagnostic advantage has not been validated.<h4>Purpose</h4>To evaluate if stretched- (SE) and bi-exponential (BE) T_1ρ models can improve early knee OA detection over the ME model.<h4>Study type</h4>Case-control study.<h4>Population</h4>Twenty-six healthy subjects (mean age 51.5) and 26 early knee OA patients (mean age 61.8).<h4>Field strength/sequence</h4>T_1ρ-prepared Turbo FLASH sequence at 3 T field strength.<h4>Assessment</h4>T_1ρ parameters from thrJournal of magnetic resonance imaging : JMRIhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12910345biostudies-literatureDetection of Early Knee Osteoarthritis Using Multi-Component T&lt;sub&gt;1ρ&lt;/sub&gt; Mapping.PMC12910345R01-AR076985R01 AR076328R01 AR078308P41 EB017183R01-AR076328R01-AR078308R01 AR076985Samuels Jde Moura HLRegatte RRSingh DZibetti MVWMonga AfalseDetection of Early Knee Osteoarthritis Using Multi-Component T&lt;sub&gt;1ρ&lt;/sub&gt; Mapping.<h4>Background</h4>Early detection of knee osteoarthritis (OA) is important. Spin-lattice relaxation in the rotating frame (T_1ρ) mapping is sensitive to early cartilage changes, but the mono-exponential (ME) model may be limited. Multi-component models can capture more tissue complexity, but their diagnostic advantage has not been validated.<h4>Purpose</h4>To evaluate if stretched- (SE) and bi-exponential (BE) T_1ρ models can improve early knee OA detection over the ME model.<h4>Study type</h4>Case-control study.<h4>Population</h4>Twenty-six healthy subjects (mean age 51.5) and 26 early knee OA patients (mean age 61.8).<h4>Field strength/sequence</h4>T_1ρ-prepared Turbo FLASH sequence at 3 T field strength.<h4>Assessment</h4>T_1ρ parameters from thr2025-01-01T00:00:00Z2025 Dec2026-07-16T03:17:03.904Z2026-07-09T10:31:12.787ZS-EPMC129103454147393910.1002/jmri.70224