biostudies-literatureUnknown16(10)Chuang YWTwo sarsolenane-type diterpenoids, including a known compound, dihydrosarsolenone (1), and a novel metabolite, sarcoglaucone A (2), were isolated from the soft coral <i>Sarcophyton glaucum</i>, collected off the coast of Taiwan. The absolute configuration of dihydrosarsolenone (1) was determined by single-crystal X-ray difraction (SC-XRD) analysis for the first time in this study. The structure of sarsolenane 2 was established on the basis of spectroscopic analysis and further confirmed by SC-XRD analysis. One aspect of the stereochemistry of the known sarsolenanes 1 (dihydrosarsolenone) and methyl dihydrosarsolenoneate was revised. Sarsolenane 1 was found to exhibit activity in enhancing alkaline phosphatase (ALP) activity in human osteoblast-like cells (MG63).RSC advances9224-9232https://www.ebi.ac.uk/biostudies/studies/S-EPMC12910705biostudies-literatureSarcoglaucone A, a novel sarsolenane-related diterpenoid from the soft coral &lt;i&gt;Sarcophyton glaucum&lt;/i&gt;.PMC12910705Chung HLChuang YWLiu YWWu YJAhmed AFPham QVLin YCWeng JRSung PJSu JHSheu JHChien SYLiaw CCfalseSarcoglaucone A, a novel sarsolenane-related diterpenoid from the soft coral &lt;i&gt;Sarcophyton glaucum&lt;/i&gt;.Two sarsolenane-type diterpenoids, including a known compound, dihydrosarsolenone (1), and a novel metabolite, sarcoglaucone A (2), were isolated from the soft coral <i>Sarcophyton glaucum</i>, collected off the coast of Taiwan. The absolute configuration of dihydrosarsolenone (1) was determined by single-crystal X-ray difraction (SC-XRD) analysis for the first time in this study. The structure of sarsolenane 2 was established on the basis of spectroscopic analysis and further confirmed by SC-XRD analysis. One aspect of the stereochemistry of the known sarsolenanes 1 (dihydrosarsolenone) and methyl dihydrosarsolenoneate was revised. Sarsolenane 1 was found to exhibit activity in enhancing alkaline phosphatase (ALP) activity in human osteoblast-like cells (MG63).2026-01-01T00:00:00Z2026 Feb2026-07-16T05:18:25.709Z2026-07-09T13:10:31.572ZS-EPMC129107054171076910.1039/d5ra09073c