{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim HK"],"funding":["Korean Society of Surgical Oncology"],"pagination":["zraf168"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911035"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>Nipple-sparing mastectomy (NSM) is a surgical option offering both oncological safety and cosmetic benefits. However, the oncological safety of NSM in carriers of BRCA1/2 pathogenic variants/likely pathogenic variants (PV/LPV) with breast cancer and the role of risk-reducing mastectomy remain underexplored, especially in Asian populations. This study evaluated the safety and effectiveness of NSM in BRCA1/2 PV/LPV carriers and assessed the preventive impact of contralateral risk-reducing NSM (RRNSM) on cancer incidence.<h4>Methods</h4>This multicentre retrospective study included women aged 20-80 years who underwent NSM for therapeutic or risk-reducing purposes and received germline BRCA1/2 tests between May 2006 and June 2022 across 19 institutions in Korea. Patients wit"],"journal":["BJS open"],"pubmed_title":["Oncological safety and preventive impact of nipple-sparing mastectomy in patients with BRCA1/2 mutation: multicentre study of the Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG)."],"pmcid":["PMC12911035"],"funding_grant_id":["KSSO-21-05"],"pubmed_authors":["Kim D","Shin DS","Lee JE","Kim YY","Bae SY","Lee J","Kim KS","Lee ES","Park HS","Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG)","Chang YW","Kang YJ","Shin HC","Choi JE","Nam SE","Kim MK","Lee JH","Shin HJ","Kim HK","Lee MH","Kwon SU","Jang SY","Choi HJ","Lee HY","Lee SB","Ye Kim J","Kim EY","Kim S","Min J","Bae SJ","Choi YJ","Ryu JM","Kim JH","Kim Z","Ko BS","Cha CD","Han SA","Park E"],"additional_accession":[]},"is_claimable":false,"name":"Oncological safety and preventive impact of nipple-sparing mastectomy in patients with BRCA1/2 mutation: multicentre study of the Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG).","description":"<h4>Background</h4>Nipple-sparing mastectomy (NSM) is a surgical option offering both oncological safety and cosmetic benefits. However, the oncological safety of NSM in carriers of BRCA1/2 pathogenic variants/likely pathogenic variants (PV/LPV) with breast cancer and the role of risk-reducing mastectomy remain underexplored, especially in Asian populations. This study evaluated the safety and effectiveness of NSM in BRCA1/2 PV/LPV carriers and assessed the preventive impact of contralateral risk-reducing NSM (RRNSM) on cancer incidence.<h4>Methods</h4>This multicentre retrospective study included women aged 20-80 years who underwent NSM for therapeutic or risk-reducing purposes and received germline BRCA1/2 tests between May 2006 and June 2022 across 19 institutions in Korea. Patients wit","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-16T04:59:06.638Z","creation":"2026-07-09T13:10:05.363Z"},"accession":"S-EPMC12911035","cross_references":{"pubmed":["41701219"],"doi":["10.1093/bjsopen/zraf168"]}}