{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(2)"],"submitter":["McWilliam OH"],"funding":["Overretssagfører L. Zeuthens Mindelegat","Jascha Fonden","Rigshospitalet's Research Council","Grosserer L. F. Foghts Fond","Ellen Mørchs Fond","Alzheimer-Forskningsfonden","Harboefonden","Aase og Ejnar Danielsens Fond","Kong Christian den Tiendes Fond"],"pubmed_abstract":["<h4>Background</h4>Early identification of pathological α-synuclein deposition (αSynD) may improve understanding of Lewy body disorder (LBD) progression and enable timely disease-modifying treatments.<h4>Objectives</h4>We investigated αSynD using a seed amplification assay and assessed prodromal LBD symptoms in individuals with idiopathic olfactory dysfunction (iOD).<h4>Methods</h4>In this cross-sectional, case-control study, we included iOD participants and normosmic healthy controls (HC) aged 55 to 75 years without diagnoses of dementia with Lewy bodies, Parkinson's disease (PD), or other major neurological disorders. iOD was defined as hyposmia without any known causes. The primary outcome was αSynD detection in skin and olfactory mucosa. Secondary outcomes included prodromal LBD sympto"],"journal":["Movement disorders clinical practice"],"pagination":["494-502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911455"],"repository":["biostudies-literature"],"pubmed_title":["Prodromal Lewy Body Symptoms and α-Synuclein Seeding in Idiopathic Olfactory Dysfunction."],"pmcid":["PMC12911455"],"pubmed_authors":["Bruun M","Pedersen CK","Hasselbalch SG","Andersen LSN","Pinborg CH","Bech M","Andersen ISB","von Buchwald C","Bsoul R","McWilliam OH","Lund EL","Frederiksen KS","Aanæs K","Simonsen AH","Areskeviciute A","Waldemar G"],"additional_accession":[]},"is_claimable":false,"name":"Prodromal Lewy Body Symptoms and α-Synuclein Seeding in Idiopathic Olfactory Dysfunction.","description":"<h4>Background</h4>Early identification of pathological α-synuclein deposition (αSynD) may improve understanding of Lewy body disorder (LBD) progression and enable timely disease-modifying treatments.<h4>Objectives</h4>We investigated αSynD using a seed amplification assay and assessed prodromal LBD symptoms in individuals with idiopathic olfactory dysfunction (iOD).<h4>Methods</h4>In this cross-sectional, case-control study, we included iOD participants and normosmic healthy controls (HC) aged 55 to 75 years without diagnoses of dementia with Lewy bodies, Parkinson's disease (PD), or other major neurological disorders. iOD was defined as hyposmia without any known causes. The primary outcome was αSynD detection in skin and olfactory mucosa. Secondary outcomes included prodromal LBD sympto","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T05:13:04.425Z","creation":"2026-07-09T10:37:47.006Z"},"accession":"S-EPMC12911455","cross_references":{"pubmed":["40916858"],"doi":["10.1002/mdc3.70333"]}}