biostudies-literatureLeite-Barbosa OConselho Nacional de Desenvolvimento Científico e TecnológicoCarlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ)National Council for Scientific and Technological Development (CNPq)e70048https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911472biostudies-literatureUnknown40(10)<h4>Rationale</h4>The migration of phthalate plasticizers from high-volume polymers, such as poly(vinyl chloride) (PVC), raises significant toxicological concerns, particularly when materials are subjected to aging and environmental stress. As traditional monitoring techniques rely on time-consuming solvent extraction and chromatographic methods that are often expensive and lack the throughput required for large-scale safety screening, this study intends to present a rapid screening method using direct analysis in real time coupled to high-resolution mass spectrometry (DART-HRMS) to monitor plasticizer migration in PVC films subjected to accelerated UV aging. Operational parameters, such as ionization gas temperature and grid voltage, were systematically optimized to balance desorption effRapid communications in mass spectrometry : RCMRapid Detection of Plasticizer Migration From UV-Aged PVC Films by DART-HRMS.PMC12911472310782/2022-8E-26/200.512/2023E-26/211.315/2021310782/2022‐8Padilha MCVeiga-Junior VFde Oliveira MGLeite-Barbosa Ode Oliveira MFLfalseRapid Detection of Plasticizer Migration From UV-Aged PVC Films by DART-HRMS.<h4>Rationale</h4>The migration of phthalate plasticizers from high-volume polymers, such as poly(vinyl chloride) (PVC), raises significant toxicological concerns, particularly when materials are subjected to aging and environmental stress. As traditional monitoring techniques rely on time-consuming solvent extraction and chromatographic methods that are often expensive and lack the throughput required for large-scale safety screening, this study intends to present a rapid screening method using direct analysis in real time coupled to high-resolution mass spectrometry (DART-HRMS) to monitor plasticizer migration in PVC films subjected to accelerated UV aging. Operational parameters, such as ionization gas temperature and grid voltage, were systematically optimized to balance desorption eff2026-01-01T00:00:00Z2026 May2026-07-16T00:35:24.089Z2026-07-09T10:25:54.024ZS-EPMC129114724170086610.1002/rcm.70048