{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yii F"],"funding":["Edinburgh Futures Institute","Medical Research Council","Diabetes UK","Visual Research Trust"],"pagination":["204-211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911562"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(2)"],"pubmed_abstract":["<h4>Aims</h4>To conduct the first cross-sectional epidemiological investigation of pathologic myopia (PM) in UK adults with high myopia.<h4>Methods</h4>Fundus photographs of 3024 highly myopic eyes (spherical equivalent refraction (SER) ≤-5.00D) from 2000 randomly sampled adults (aged 40-70 years) in the UK Biobank were double graded by an ophthalmic reading centre using the Meta-analysis for Pathologic Myopia framework. Adjudication was performed by one of two retinal specialists. Multivariable mixed-effects logistic regression was used to explore potential risk factors and fundus biomarkers-initially adjusting for SER, age and sex, before including these and other variables with p<0.10 in a single model.<h4>Results</h4>PM was present in 1138 of 3006 gradable fundus photographs, with 41.7"],"journal":["The British journal of ophthalmology"],"pubmed_title":["Epidemiology of pathologic myopia in UK adults with high myopia."],"pmcid":["PMC12911562"],"funding_grant_id":["N/A","SCOO4516","MR/N013166/1","20/0006221"],"pubmed_authors":["Strang N","Dhillon B","Bernabeu MO","MacCormick IJC","MacGillivray T","Yii F"],"additional_accession":[]},"is_claimable":false,"name":"Epidemiology of pathologic myopia in UK adults with high myopia.","description":"<h4>Aims</h4>To conduct the first cross-sectional epidemiological investigation of pathologic myopia (PM) in UK adults with high myopia.<h4>Methods</h4>Fundus photographs of 3024 highly myopic eyes (spherical equivalent refraction (SER) ≤-5.00D) from 2000 randomly sampled adults (aged 40-70 years) in the UK Biobank were double graded by an ophthalmic reading centre using the Meta-analysis for Pathologic Myopia framework. Adjudication was performed by one of two retinal specialists. Multivariable mixed-effects logistic regression was used to explore potential risk factors and fundus biomarkers-initially adjusting for SER, age and sex, before including these and other variables with p<0.10 in a single model.<h4>Results</h4>PM was present in 1138 of 3006 gradable fundus photographs, with 41.7","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T00:45:51.956Z","creation":"2026-07-09T10:26:20.413Z"},"accession":"S-EPMC12911562","cross_references":{"pubmed":["40854736"],"doi":["10.1136/bjo-2024-326889"]}}