biostudies-literatureYii FEdinburgh Futures InstituteMedical Research CouncilDiabetes UKVisual Research Trust204-211https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911562biostudies-literatureUnknown110(2)<h4>Aims</h4>To conduct the first cross-sectional epidemiological investigation of pathologic myopia (PM) in UK adults with high myopia.<h4>Methods</h4>Fundus photographs of 3024 highly myopic eyes (spherical equivalent refraction (SER) ≤-5.00D) from 2000 randomly sampled adults (aged 40-70 years) in the UK Biobank were double graded by an ophthalmic reading centre using the Meta-analysis for Pathologic Myopia framework. Adjudication was performed by one of two retinal specialists. Multivariable mixed-effects logistic regression was used to explore potential risk factors and fundus biomarkers-initially adjusting for SER, age and sex, before including these and other variables with p<0.10 in a single model.<h4>Results</h4>PM was present in 1138 of 3006 gradable fundus photographs, with 41.7The British journal of ophthalmologyEpidemiology of pathologic myopia in UK adults with high myopia.PMC12911562N/ASCOO4516MR/N013166/120/0006221Strang NDhillon BBernabeu MOMacCormick IJCMacGillivray TYii FfalseEpidemiology of pathologic myopia in UK adults with high myopia.<h4>Aims</h4>To conduct the first cross-sectional epidemiological investigation of pathologic myopia (PM) in UK adults with high myopia.<h4>Methods</h4>Fundus photographs of 3024 highly myopic eyes (spherical equivalent refraction (SER) ≤-5.00D) from 2000 randomly sampled adults (aged 40-70 years) in the UK Biobank were double graded by an ophthalmic reading centre using the Meta-analysis for Pathologic Myopia framework. Adjudication was performed by one of two retinal specialists. Multivariable mixed-effects logistic regression was used to explore potential risk factors and fundus biomarkers-initially adjusting for SER, age and sex, before including these and other variables with p<0.10 in a single model.<h4>Results</h4>PM was present in 1138 of 3006 gradable fundus photographs, with 41.72026-01-01T00:00:00Z2026 Jan2026-07-16T00:45:51.956Z2026-07-09T10:26:20.413ZS-EPMC129115624085473610.1136/bjo-2024-326889