{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang W"],"funding":["Nanjing Medical University Fan Daiming Research Funds for Holistic Integrative Medicine","National Key Research and Development Program of China"],"pagination":["289-301"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911655"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(2)"],"pubmed_abstract":["<h4>Background</h4>Current microbiome-based therapeutics face two prominent issues: the limited clinical efficacy of probiotics and the significant variability in the efficacy of microbiota transplantation across different diseases. Although washed microbiota transplantation (WMT) is a new faecal microbiota transplantation, a single therapeutic agent cannot be universally effective for multiple dysbiosis-related diseases.<h4>Objective</h4>We introduced a new therapeutic concept, X-augmented WMT (X-auWMT), which combines a disease-specific beneficial microbe, 'X', with WMT to enhance its effectiveness. Our goal was to identify a candidate 'X' bacterium to augment WMT efficacy and examine the efficacy of X-auWMT in animal models of radiation enteritis (RE).<h4>Design</h4>We conducted a prosp"],"journal":["Gut"],"pubmed_title":["&lt;i&gt;Holdemanella biformis&lt;/i&gt; augments washed microbiota transplantation for the treatment of radiation enteritis."],"pmcid":["PMC12911655"],"funding_grant_id":["2023-3HIM","2021YFA0717004"],"pubmed_authors":["Zhang F","Lu C","Wen Q","Li P","Zhang L","Zhang S","Liang C","Ding X","Lu G","Wang R","Yi B","Wang W","Bai J","Wang Y","Yu Y","Cui B"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Holdemanella biformis&lt;/i&gt; augments washed microbiota transplantation for the treatment of radiation enteritis.","description":"<h4>Background</h4>Current microbiome-based therapeutics face two prominent issues: the limited clinical efficacy of probiotics and the significant variability in the efficacy of microbiota transplantation across different diseases. Although washed microbiota transplantation (WMT) is a new faecal microbiota transplantation, a single therapeutic agent cannot be universally effective for multiple dysbiosis-related diseases.<h4>Objective</h4>We introduced a new therapeutic concept, X-augmented WMT (X-auWMT), which combines a disease-specific beneficial microbe, 'X', with WMT to enhance its effectiveness. Our goal was to identify a candidate 'X' bacterium to augment WMT efficacy and examine the efficacy of X-auWMT in animal models of radiation enteritis (RE).<h4>Design</h4>We conducted a prosp","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T07:11:47.242Z","creation":"2026-07-09T10:43:13.497Z"},"accession":"S-EPMC12911655","cross_references":{"pubmed":["40947138"],"doi":["10.1136/gutjnl-2025-335230"]}}