{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Williams EI"],"funding":["National Institute for Health Research (NIHR)"],"pagination":["80-88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911656"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["80(2)"],"pubmed_abstract":["<h4>Background</h4>Socioeconomic status (SES) is a potentially important upstream determinant of late-life cognitive health, but a review which captures the dynamic influence of SES across the life-course is lacking. We conducted a systematic review of studies reporting associations between life-course SES and dementia/late-life cognitive decline.<h4>Methods</h4>On 21 February 2024, we searched Medline, Embase, PsycINFO, CINAHL, British Education Index, Web of Science, Scopus and Advanced Google for studies related to life-course SES and dementia. We included studies employing trajectory or mediation analysis that measured dementia/cognitive decline as outcomes. Two researchers independently screened articles and assessed risk of bias. Results were synthesised narratively and in Harvest plots.<h4>Results</h4>We included 18 out of 6040 studies screened (n=7 trajectory studies, n=8 mediation studies, n=3 both). Most (13/23) trajectory analyses reported that stable low SES and downward social mobility, relative to stable high SES/upward mobility, were linked to higher dementia and/or cognitive decline risk. Half (5/10) of the mediation analyses reported full mediation of adulthood SES on the association between childhood SES and dementia/cognitive decline, and 4/10 reported partial mediation. Overall, study quality was moderate.<h4>Conclusion</h4>SES has a dynamic life-course association with dementia risk. Increases in dementia risk are compounded by sustained life-course disadvantage. Policies to address socioeconomic disadvantage across the life-course are needed to address this upstream determinant of dementia.<h4>Prospero registration number</h4>CRD42024505975."],"journal":["Journal of epidemiology and community health"],"pubmed_title":["Systematic review of the association between life-course socioeconomic status and late-life cognitive decline."],"pmcid":["PMC12911656"],"funding_grant_id":["NIHR302276"],"pubmed_authors":["Walsh S","Kuhn I","Williams EI","Brayne CE"],"additional_accession":[]},"is_claimable":false,"name":"Systematic review of the association between life-course socioeconomic status and late-life cognitive decline.","description":"<h4>Background</h4>Socioeconomic status (SES) is a potentially important upstream determinant of late-life cognitive health, but a review which captures the dynamic influence of SES across the life-course is lacking. We conducted a systematic review of studies reporting associations between life-course SES and dementia/late-life cognitive decline.<h4>Methods</h4>On 21 February 2024, we searched Medline, Embase, PsycINFO, CINAHL, British Education Index, Web of Science, Scopus and Advanced Google for studies related to life-course SES and dementia. We included studies employing trajectory or mediation analysis that measured dementia/cognitive decline as outcomes. Two researchers independently screened articles and assessed risk of bias. Results were synthesised narratively and in Harvest plots.<h4>Results</h4>We included 18 out of 6040 studies screened (n=7 trajectory studies, n=8 mediation studies, n=3 both). Most (13/23) trajectory analyses reported that stable low SES and downward social mobility, relative to stable high SES/upward mobility, were linked to higher dementia and/or cognitive decline risk. Half (5/10) of the mediation analyses reported full mediation of adulthood SES on the association between childhood SES and dementia/cognitive decline, and 4/10 reported partial mediation. Overall, study quality was moderate.<h4>Conclusion</h4>SES has a dynamic life-course association with dementia risk. Increases in dementia risk are compounded by sustained life-course disadvantage. Policies to address socioeconomic disadvantage across the life-course are needed to address this upstream determinant of dementia.<h4>Prospero registration number</h4>CRD42024505975.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-09T13:14:28.189Z","creation":"2026-07-09T13:10:12.354Z"},"accession":"S-EPMC12911656","cross_references":{"pubmed":["41130718"],"doi":["10.1136/jech-2025-223864"]}}