{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mercado-Gomez M"],"funding":["Ramon y Cajal Program","AECC Scientific Foundation","La Caixa","MICINN","Miguel Servet","Instituto de Salud Carlos III","CIMA, Pamplona","Jose Juan García Marín","Spanish Ministry of Science and Innovation","European Regional Development Fund/European Social Fund","AECC","Fundação para a Ciência e a Tecnologia, Portugal","Universidad de Salamanca","PNRR","Sara Borrell","Health Research","CUP","Department of Health of the Basque Country","FEDER","Instituto de Salud Carlos III, Spain","McGill University","Carlos III Health Institute","MINECO","Ministerio de Ciencia e Innovación, Programa Retos-Colaboración RTC2019","European Union","Ayudas Fundación Científica AECC para proyectos coordinados","National Cancer Institute of the National Institutes of Health"],"pagination":["341-352"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911659"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(2)"],"pubmed_abstract":["<h4>Background and objective</h4>Cholangiocarcinoma (CCA) is a heterogeneous neoplasm of the biliary epithelium that easily infiltrates, metastasises and recurs. Magnesium disbalance is a hallmark of CCA, with the magnesium transporter cyclin M4 (CNNM4) being a key driver of various hepatic diseases. This study aims to unravel the role of CNNM4 in the initiation and progression of CCA.<h4>Design</h4>CNNM4 protein and gene expression were assessed in vitro, in vivo and in patients with CCA. Silencing of <i>CNNM4</i> was effectively achieved by using small interfering RNA (siRNA) or short hairpin RNA in CCA cell lines and GalNAc-conjugated siRNA in a transposon-based CCA mice model. The impact of CNNM4 on tumour cell proliferation, migration and invasion to the lungs was evaluated using the "],"journal":["Gut"],"pubmed_title":["Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential."],"pmcid":["PMC12911659"],"funding_grant_id":["N/A","PRE2021-097073","2023-CIEN-000008-01","LCF/PR/HR21/52410028","PRDVZ233980ZAPA","IGTP-AECC_2022-042","2023333041","PRE2018-084840","2020-CIEN-000067-01","2022111070","EXOHEP2-CM","2023/2027","PI21/00922","FAR/3492/2021","S2022/BMD-7409","DTS20/00138","CP22/00073","2021-CIEN-000029-04-01","CI23-20155","6/12/TT/2022/00001","PI18/01075","R01CA127817","PI23/01850","PNC 0000001","CEX2021-001136-S","PI23/00681","PID2021-126096NB-I00","RYC2018-024475-1","SEV‐2016‐0644","CPII19/00008","HORIZON-HLTH-2022-STAYHLTH-02","RED2018-102379-T","PID2020-117116RB-I00","20222J7W2K","CN00000041","HR17-00601","SA113P23","101095679","CD19/00254","PID2020-117941RB","I00/AEI/10.13039","PI22/00526","B53C22006120001"],"pubmed_authors":["Rodrigues PM","Rodriguez-Agudo R","Martinez-Cruz LA","Buccella D","Gonzalez Recio I","Mendizabal I","Lamarca A","Carpino G","Wu H","Martinez-Chantar ML","Macarulla T","Rejano-Gordillo CM","Cubero FJ","Singh R","Tian TV","Yanez-Bartolome M","Azkargorta M","Gine AE","Carracedo A","Merlos Rodrigo MA","G Fernandez-Barrena M","Barrenechea-Barrenechea JA","Banales J","Romero MR","Calvisi DF","Elortza F","Mercado-Gomez M","Schaeper U","Garcia-Longarte S","Lapitz A","Michalkova H","Macias RIR","Afonso MB","Gaudio E","Pena-SanFelix P","Delgado TC","Heger Z","Zapata-Pavas LE","Rodrigues CMP","Conter C","Serrano-Macia M","Martin C","Gil-Pitarch C","Marin JJG","Overi D","Moreno V","Olaizola P","Goikoetxea-Usandizaga N","Avila MA"],"additional_accession":[]},"is_claimable":false,"name":"Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential.","description":"<h4>Background and objective</h4>Cholangiocarcinoma (CCA) is a heterogeneous neoplasm of the biliary epithelium that easily infiltrates, metastasises and recurs. Magnesium disbalance is a hallmark of CCA, with the magnesium transporter cyclin M4 (CNNM4) being a key driver of various hepatic diseases. This study aims to unravel the role of CNNM4 in the initiation and progression of CCA.<h4>Design</h4>CNNM4 protein and gene expression were assessed in vitro, in vivo and in patients with CCA. Silencing of <i>CNNM4</i> was effectively achieved by using small interfering RNA (siRNA) or short hairpin RNA in CCA cell lines and GalNAc-conjugated siRNA in a transposon-based CCA mice model. The impact of CNNM4 on tumour cell proliferation, migration and invasion to the lungs was evaluated using the ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T00:33:05.676Z","creation":"2026-07-09T13:10:01.392Z"},"accession":"S-EPMC12911659","cross_references":{"pubmed":["40764063"],"doi":["10.1136/gutjnl-2024-333255"]}}