{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(2)"],"submitter":["Minami S"],"pubmed_abstract":["<h4>Objectives</h4>The Trauma and Injury Severity Score (TRISS) is widely used to predict survival in patients with trauma; however, its predictive accuracy in paediatric populations remains suboptimal. In contrast, the revised Shock Index multiplied by the Glasgow Coma Scale (rSIG), a simple physiological marker, has shown potential utility in adults and children. Therefore, we aimed to compare the predictive performance of rSIG and TRISS in paediatric patients with trauma.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>Japan Trauma Data Bank.<h4>Participants</h4>Paediatric patients with trauma aged ≤17 years who were registered in the Japan Trauma Data Bank between 2009 and 2021.<h4>Primary and secondary outcome measures</h4>The optimal cut-off value for rSIG was determined using the derivation cohort (2009-2018). In the validation cohort (2019-2021), the predictive accuracy of rSIG and TRISS for in-hospital survival was compared using the area under the receiver operating characteristic curve (AUC).<h4>Results</h4>In the derivation cohort, the optimal cut-off value for rSIG was 10.13. In the validation cohort, the overall AUC for rSIG was 0.857 (95% CI 0.796 to 0.918) compared with 0.740 (95% CI 0.661 to 0.820) for TRISS, demonstrating the significantly superior predictive accuracy of rSIG (p=0.006). Age-stratified analyses revealed that rSIG significantly outperformed TRISS in the 7-12 and 13-17 age groups.<h4>Conclusions</h4>The rSIG demonstrated higher predictive accuracy for in-hospital survival among paediatric patients with trauma than TRISS. These findings suggest that rSIG is a more effective prognostic tool for paediatric trauma care. Validation and the establishment of age-specific cut-off values are warranted to enhance its clinical applicability."],"journal":["BMJ open"],"pagination":["e110427"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911708"],"repository":["biostudies-literature"],"pubmed_title":["Comparison of the revised Shock Index multiplied by the Glasgow Coma Scale and the Trauma and Injury Severity Score for predicting survival in paediatric patients with trauma: a nationwide retrospective cohort study in Japan."],"pmcid":["PMC12911708"],"pubmed_authors":["Toida C","Minami S"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of the revised Shock Index multiplied by the Glasgow Coma Scale and the Trauma and Injury Severity Score for predicting survival in paediatric patients with trauma: a nationwide retrospective cohort study in Japan.","description":"<h4>Objectives</h4>The Trauma and Injury Severity Score (TRISS) is widely used to predict survival in patients with trauma; however, its predictive accuracy in paediatric populations remains suboptimal. In contrast, the revised Shock Index multiplied by the Glasgow Coma Scale (rSIG), a simple physiological marker, has shown potential utility in adults and children. Therefore, we aimed to compare the predictive performance of rSIG and TRISS in paediatric patients with trauma.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>Japan Trauma Data Bank.<h4>Participants</h4>Paediatric patients with trauma aged ≤17 years who were registered in the Japan Trauma Data Bank between 2009 and 2021.<h4>Primary and secondary outcome measures</h4>The optimal cut-off value for rSIG was determined using the derivation cohort (2009-2018). In the validation cohort (2019-2021), the predictive accuracy of rSIG and TRISS for in-hospital survival was compared using the area under the receiver operating characteristic curve (AUC).<h4>Results</h4>In the derivation cohort, the optimal cut-off value for rSIG was 10.13. In the validation cohort, the overall AUC for rSIG was 0.857 (95% CI 0.796 to 0.918) compared with 0.740 (95% CI 0.661 to 0.820) for TRISS, demonstrating the significantly superior predictive accuracy of rSIG (p=0.006). Age-stratified analyses revealed that rSIG significantly outperformed TRISS in the 7-12 and 13-17 age groups.<h4>Conclusions</h4>The rSIG demonstrated higher predictive accuracy for in-hospital survival among paediatric patients with trauma than TRISS. These findings suggest that rSIG is a more effective prognostic tool for paediatric trauma care. Validation and the establishment of age-specific cut-off values are warranted to enhance its clinical applicability.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T03:16:55.717Z","creation":"2026-07-09T10:31:11.96Z"},"accession":"S-EPMC12911708","cross_references":{"pubmed":["41667179"],"doi":["10.1136/bmjopen-2025-110427"]}}