{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Diego JG-B"],"funding":["National Institute of Allergy and Infectious Diseases","Ministerio de Ciencia e Innovación"],"pagination":["e0177425"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12911902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["100(2)"],"pubmed_abstract":["Secondary bacterial infections can significantly worsen the clinical course of influenza virus infections and are a leading cause of morbidity and mortality during seasonal influenza epidemics. Despite being a vaccine-preventable disease, influenza-related complications from secondary bacterial infections are an important cause of death, particularly among the elderly population. <i>Streptococcus pneumoniae</i> (Spn) is the most common agent responsible for influenza-related secondary bacterial infections. Influenza virus vaccination serves as an effective prophylactic strategy for preventing influenza and reducing the burden of influenza-associated pathology, including secondary bacterial infection. However, whether the protective effects of influenza virus vaccination differ in the conte"],"journal":["Journal of virology"],"pubmed_title":["Disease modulation by TIV vaccination during secondary pneumococcal infections in influenza-infected mice."],"pmcid":["PMC12911902"],"funding_grant_id":["PID2019-105761RB-100, PID2023-150116OB-I00, MICIU/AEI /10.13039/501100011033/FEDER","R21AI151229, R21AI176069, 75N93021C00014, 75N93019C00051"],"pubmed_authors":["Singh G","Diego JG-B","Arranz-Herrero J","Schotsaert M","Park S-C","Warang P","Chang LA","Ochando J","Nistal-Villan E","Laghlali G","Burgess E","Noureddine M"],"additional_accession":[]},"is_claimable":false,"name":"Disease modulation by TIV vaccination during secondary pneumococcal infections in influenza-infected mice.","description":"Secondary bacterial infections can significantly worsen the clinical course of influenza virus infections and are a leading cause of morbidity and mortality during seasonal influenza epidemics. Despite being a vaccine-preventable disease, influenza-related complications from secondary bacterial infections are an important cause of death, particularly among the elderly population. <i>Streptococcus pneumoniae</i> (Spn) is the most common agent responsible for influenza-related secondary bacterial infections. Influenza virus vaccination serves as an effective prophylactic strategy for preventing influenza and reducing the burden of influenza-associated pathology, including secondary bacterial infection. However, whether the protective effects of influenza virus vaccination differ in the conte","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T00:47:34.098Z","creation":"2026-07-09T10:26:30.729Z"},"accession":"S-EPMC12911902","cross_references":{"pubmed":["41459948"],"doi":["10.1128/jvi.01774-25"]}}