{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wan H"],"funding":["Natural Sciences and Engineering Research Council of Canada","University of Toronto"],"pagination":["dev204843"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12912265"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["153(3)"],"pubmed_abstract":["In zebrafish, epiboly is a major morphogenic event during gastrulation, characterized by the thinning and spreading of the embryonic blastoderm to internalize the underlying extra-embryonic yolk cell. This movement is driven by the yolk cell, which generates motile force through actomyosin flow that engages a circumferential contractile band, pulling the attached blastoderm vegetally. Localized macropinocytosis of the yolk cell, another actin-driven process, also contributes to epiboly progression by removing yolk membrane ahead of the advancing blastoderm. The molecular mechanisms coordinating these processes are elusive. Here, we identified Camsap2a, a non-centrosomal, microtubule-stabilizing protein, as a regulator of actin-dependent processes in the yolk cell during epiboly. Epiboly is"],"journal":["Development (Cambridge, England)"],"pubmed_title":["Camsap2a regulates actomyosin flow and Rab5ab-mediated macropinocytosis in the yolk cell during zebrafish epiboly."],"pmcid":["PMC12912265"],"funding_grant_id":["458019","201009"],"pubmed_authors":["Quibria S","Iu E","User SD","Bruce AEE","Wan H","Plotnikov SV"],"additional_accession":[]},"is_claimable":false,"name":"Camsap2a regulates actomyosin flow and Rab5ab-mediated macropinocytosis in the yolk cell during zebrafish epiboly.","description":"In zebrafish, epiboly is a major morphogenic event during gastrulation, characterized by the thinning and spreading of the embryonic blastoderm to internalize the underlying extra-embryonic yolk cell. This movement is driven by the yolk cell, which generates motile force through actomyosin flow that engages a circumferential contractile band, pulling the attached blastoderm vegetally. Localized macropinocytosis of the yolk cell, another actin-driven process, also contributes to epiboly progression by removing yolk membrane ahead of the advancing blastoderm. The molecular mechanisms coordinating these processes are elusive. Here, we identified Camsap2a, a non-centrosomal, microtubule-stabilizing protein, as a regulator of actin-dependent processes in the yolk cell during epiboly. Epiboly is","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T00:38:21.481Z","creation":"2026-07-09T10:26:26.435Z"},"accession":"S-EPMC12912265","cross_references":{"pubmed":["41627452"],"doi":["10.1242/dev.204843"]}}