{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["228(3)"],"submitter":["Myhre MO"],"pubmed_abstract":["<h4>Background</h4>Self-harm, self-poisoning or self-injury, irrespective of the motivation, is a central risk factor for suicide. Still, there is limited knowledge of self-harm among patients with substance use disorders (SUDs) who die by suicide.<h4>Aims</h4>We aimed to describe the prevalence of a history of self-harm and identify the factors associated with self-harm, comparing individuals who died by suicide with and without SUDs.<h4>Method</h4>We used data from the Norwegian Surveillance System for Suicide in Mental Health and Substance Use Services, which is based on a national linkage between the Norwegian Cause of Death Registry and the Norwegian Patient Registry, to identify individuals who died by suicide within 1 year after last contact with mental health or substance use services (<i>n</i> = 1140). A questionnaire was retrieved for 1041 (91.3%) of these individuals. We used least absolute shrinkage and selection operator (LASSO) regression to select variables and compared patients with and without SUDs. Conditional selective inference was used to improve 90% confidence intervals and <i>p</i>-values.<h4>Results</h4>The prevalence of self-harm was 55% in patients with SUDs and 52.6% in patients without SUDs. Suicidal ideation (odds ratio 2.98 (95% CI 1.74-5.10)) emerged as a factor shared with patients without SUDs, while personality disorders (odds ratio 1.96 (1.12-3.40)) and a history of violence (odds ratio 1.86 (1.20-2.87)) were unique factors for patients with SUDs.<h4>Conclusions</h4>A history of self-harm is prevalent in patients with SUDs who die by suicide and is associated with suicidal ideation, a history of violence and personality disorders in patients with SUDs."],"journal":["The British journal of psychiatry : the journal of mental science"],"pagination":["229-235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12912876"],"repository":["biostudies-literature"],"pubmed_title":["Factors associated with self-harm in patients with substance use disorders who died by suicide: national hybrid questionnaire registry study."],"pmcid":["PMC12912876"],"pubmed_authors":["Mehlum L","Bramness JG","Walby FA","Klungsoyr O","Myhre MO"],"additional_accession":[]},"is_claimable":false,"name":"Factors associated with self-harm in patients with substance use disorders who died by suicide: national hybrid questionnaire registry study.","description":"<h4>Background</h4>Self-harm, self-poisoning or self-injury, irrespective of the motivation, is a central risk factor for suicide. Still, there is limited knowledge of self-harm among patients with substance use disorders (SUDs) who die by suicide.<h4>Aims</h4>We aimed to describe the prevalence of a history of self-harm and identify the factors associated with self-harm, comparing individuals who died by suicide with and without SUDs.<h4>Method</h4>We used data from the Norwegian Surveillance System for Suicide in Mental Health and Substance Use Services, which is based on a national linkage between the Norwegian Cause of Death Registry and the Norwegian Patient Registry, to identify individuals who died by suicide within 1 year after last contact with mental health or substance use services (<i>n</i> = 1140). A questionnaire was retrieved for 1041 (91.3%) of these individuals. We used least absolute shrinkage and selection operator (LASSO) regression to select variables and compared patients with and without SUDs. Conditional selective inference was used to improve 90% confidence intervals and <i>p</i>-values.<h4>Results</h4>The prevalence of self-harm was 55% in patients with SUDs and 52.6% in patients without SUDs. Suicidal ideation (odds ratio 2.98 (95% CI 1.74-5.10)) emerged as a factor shared with patients without SUDs, while personality disorders (odds ratio 1.96 (1.12-3.40)) and a history of violence (odds ratio 1.86 (1.20-2.87)) were unique factors for patients with SUDs.<h4>Conclusions</h4>A history of self-harm is prevalent in patients with SUDs who die by suicide and is associated with suicidal ideation, a history of violence and personality disorders in patients with SUDs.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-09T13:11:42.107Z","creation":"2026-07-09T13:09:43.201Z"},"accession":"S-EPMC12912876","cross_references":{"pubmed":["40143678"],"doi":["10.1192/bjp.2025.22"]}}