{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["123(7)"],"submitter":["Arnold MFF"],"pubmed_abstract":["Some legumes encode families of NCR (Nodule-Cysteine-Rich) peptides that cause their rhizobial partners to terminally differentiate during the development of a nitrogen-fixing symbiosis. <i>Sinorhizobium meliloti,</i> whose plant hosts <i>Medicago truncatula</i> and <i>Medicago sativa</i> express <i>ca.</i> 600 NCR peptides during root nodule development, possesses a symbiotically essential BacA<i><sub>Sm</sub></i> protein that imports certain NCR peptides into the cytoplasm. This import permits proteolytic degradation of the NCR peptides, thereby protecting the endocytosed bacteria from their antimicrobial peptide-like lethality, while also allowing certain NCR peptides to undergo their symbiotically critical interactions with cytoplasmic components, for example heme-sequestration in the "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["e2526811123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12912959"],"repository":["biostudies-literature"],"pubmed_title":["BacA(SbmA) importer of legume symbiotic NCR peptides: Protein architecture, function, and evolutionary implications."],"pmcid":["PMC12912959"],"pubmed_authors":["Sankari S","Gruber CC","Guerra-Garcia FJ","Arnold MFF","Deutsch M","Beis K","Walker GC"],"additional_accession":[]},"is_claimable":false,"name":"BacA(SbmA) importer of legume symbiotic NCR peptides: Protein architecture, function, and evolutionary implications.","description":"Some legumes encode families of NCR (Nodule-Cysteine-Rich) peptides that cause their rhizobial partners to terminally differentiate during the development of a nitrogen-fixing symbiosis. <i>Sinorhizobium meliloti,</i> whose plant hosts <i>Medicago truncatula</i> and <i>Medicago sativa</i> express <i>ca.</i> 600 NCR peptides during root nodule development, possesses a symbiotically essential BacA<i><sub>Sm</sub></i> protein that imports certain NCR peptides into the cytoplasm. This import permits proteolytic degradation of the NCR peptides, thereby protecting the endocytosed bacteria from their antimicrobial peptide-like lethality, while also allowing certain NCR peptides to undergo their symbiotically critical interactions with cytoplasmic components, for example heme-sequestration in the ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T06:50:14.081Z","creation":"2026-07-09T10:41:02.838Z"},"accession":"S-EPMC12912959","cross_references":{"pubmed":["41665997"],"doi":["10.1073/pnas.2526811123"]}}