{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Deshpande T"],"funding":["Core unit PIX of the Medical Faculty and the IZKF Münster","European Research Council","deutsche forschungsgemeinschaft","bundesministerium für bildung und forschung"],"pubmed_abstract":["We investigated whether basement membrane (BM) laminins influence regional differences in the vasculature by performing single-cell RNA sequencing on cerebral blood vessels from mice lacking the major vascular laminins in endothelial and smooth muscle BMs, laminin α4 (<i>Lama4</i><sup><i><sup>-/-</sup></i></sup> ) and laminin α5 (<i>Tek-cre:Lama5</i><sup><i><sup>-/-</sup></i></sup>), and wild-type littermates. Our dataset expands existing cerebral vascular transcriptomic profiles and reveals that <i>Lama4</i><sup><sup><i>-/-</i></sup></sup> endothelial cells exhibit increased arterial marker expression and reduced postcapillary venule identity. In vitro and in vivo studies indicated that compensatory upregulation of laminin α5 in <i>Lama4</i><sup><i><sup>-/-</sup></i></sup> vessels enhance"],"journal":["Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism"],"pagination":["271678X251410040"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12913041"],"repository":["biostudies-literature"],"pubmed_title":["Vascular basement membrane laminins modulate functional zonation of cerebral microvessels."],"pmcid":["PMC12913041"],"funding_grant_id":["SO285/14-1","DeCoDis","101054805"],"pubmed_authors":["Huppert J","Hannocks MJ","Samawar SK","Adams RH","Ghavampour S","Song J","Jeong HW","Deshpande T","Sorokin L","Thulichery DR","Soltwisch J","Budny S","Faber C","Meng L","Wachsmuth L","Kapupara K","Hallmann R"],"additional_accession":[]},"is_claimable":false,"name":"Vascular basement membrane laminins modulate functional zonation of cerebral microvessels.","description":"We investigated whether basement membrane (BM) laminins influence regional differences in the vasculature by performing single-cell RNA sequencing on cerebral blood vessels from mice lacking the major vascular laminins in endothelial and smooth muscle BMs, laminin α4 (<i>Lama4</i><sup><i><sup>-/-</sup></i></sup> ) and laminin α5 (<i>Tek-cre:Lama5</i><sup><i><sup>-/-</sup></i></sup>), and wild-type littermates. Our dataset expands existing cerebral vascular transcriptomic profiles and reveals that <i>Lama4</i><sup><sup><i>-/-</i></sup></sup> endothelial cells exhibit increased arterial marker expression and reduced postcapillary venule identity. In vitro and in vivo studies indicated that compensatory upregulation of laminin α5 in <i>Lama4</i><sup><i><sup>-/-</sup></i></sup> vessels enhance","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T06:52:07.974Z","creation":"2026-07-09T10:42:18.342Z"},"accession":"S-EPMC12913041","cross_references":{"pubmed":["41696806"],"doi":["10.1177/0271678X251410040"]}}