{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Wright ME"],"funding":["Wellcome Trust"],"pubmed_abstract":["The ovarian hormones, oestrogen and progesterone, have vaso- and neuroprotective effects, potentially due to cerebrovascular interactions. This study investigates their neuroendocrine influence on cerebral and retinal baseline vascular metrics across a healthy menstrual cycle. Twenty-six menstruating females completed imaging sessions and assessment of circulating hormone levels during their early follicular, late follicular and mid-luteal phase. Perfusion, arterial arrival time (AAT), global oxygen extraction fraction (OEF), cerebrovascular metabolic rate of oxygen (CMRO<sub>2</sub>), carotid artery radius and carotid pulsatility index (PI) were measured using 3 T MRI. Retinal vessel density and blood flow resistance were assessed with optical coherence tomography angiography (OCT-A). Ass"],"journal":["Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism"],"pagination":["271678X261421106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12913051"],"repository":["biostudies-literature"],"pubmed_title":["Endocrine modulation of cortical and retinal baseline perfusion across the menstrual cycle."],"pmcid":["PMC12913051"],"funding_grant_id":["WT224267","220575/Z/20/Z"],"pubmed_authors":["Driver ID","Germuska M","Wright ME","Chandler H","Bernabeu MO","Terry L","Murphy K","Giarratano Y","Rashid D","Crofts C","Steventon JJ","Davies S"],"additional_accession":[]},"is_claimable":false,"name":"Endocrine modulation of cortical and retinal baseline perfusion across the menstrual cycle.","description":"The ovarian hormones, oestrogen and progesterone, have vaso- and neuroprotective effects, potentially due to cerebrovascular interactions. This study investigates their neuroendocrine influence on cerebral and retinal baseline vascular metrics across a healthy menstrual cycle. Twenty-six menstruating females completed imaging sessions and assessment of circulating hormone levels during their early follicular, late follicular and mid-luteal phase. Perfusion, arterial arrival time (AAT), global oxygen extraction fraction (OEF), cerebrovascular metabolic rate of oxygen (CMRO<sub>2</sub>), carotid artery radius and carotid pulsatility index (PI) were measured using 3 T MRI. Retinal vessel density and blood flow resistance were assessed with optical coherence tomography angiography (OCT-A). Ass","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T06:56:07.452Z","creation":"2026-07-09T13:10:39.307Z"},"accession":"S-EPMC12913051","cross_references":{"pubmed":["41696811"],"doi":["10.1177/0271678X261421106"]}}