{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(4)"],"submitter":["da Silva AKJPF"],"funding":["FACEPE, CAPES and CNPq"],"pubmed_abstract":["Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more biocompatible and less toxic systems. Therefore, this work aim to develop a new composition formed by an oxidovanadium(IV) complex as levan. The acute oral toxicity and insulin resistance (IR) are investigated in an animal model using adult Swiss mice treated with daily injections of the synthetic glucocorticoid dexamethasone. The complex is characterized by electronic absorption (λ<sub>max</sub> = 771 and 880 nm) and infrared spectroscopies (3359, 3167, 1606, 1342, 1072 cm<sup>-1</sup>, and the VO at 937 cm<sup>-1</sup>); NMR of the <sup>1</sup>H, <sup>13</sup>C, and <sup>51</sup>V (-427, -509, and -529 ppm), and electron paramagnetic resonance (g-factor = 1.985). The vanadium complex i"],"journal":["ChemMedChem"],"pagination":["e202500754"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12913243"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice."],"pmcid":["PMC12913243"],"pubmed_authors":["Gomes DA","Marques EKLB","de Lima LMA","Silva WE","Lira EC","da Silva AKJPF","Alves WAS","Guzzo PL","Belian MF"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice.","description":"Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more biocompatible and less toxic systems. Therefore, this work aim to develop a new composition formed by an oxidovanadium(IV) complex as levan. The acute oral toxicity and insulin resistance (IR) are investigated in an animal model using adult Swiss mice treated with daily injections of the synthetic glucocorticoid dexamethasone. The complex is characterized by electronic absorption (λ<sub>max</sub> = 771 and 880 nm) and infrared spectroscopies (3359, 3167, 1606, 1342, 1072 cm<sup>-1</sup>, and the VO at 937 cm<sup>-1</sup>); NMR of the <sup>1</sup>H, <sup>13</sup>C, and <sup>51</sup>V (-427, -509, and -529 ppm), and electron paramagnetic resonance (g-factor = 1.985). The vanadium complex i","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T06:35:34.113Z","creation":"2026-07-09T10:40:00.118Z"},"accession":"S-EPMC12913243","cross_references":{"pubmed":["41407512"],"doi":["10.1002/cmdc.202500754"]}}