{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leddy JJ"],"funding":["National Center for Advancing Translational Sciences","National Institute of Neurological Disorders and Stroke","NCATS NIH HHS","NINDS NIH HHS"],"pagination":["271-282"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12913255"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(1)"],"pubmed_abstract":["<h4>Background</h4>Symptom-limited exercise intolerance is a physiological sign of sport-related concussion. Possible etiologies include rest-induced aerobic deconditioning and/or impaired cardiopulmonary function.<h4>Objective</h4>This study examined cardiovascular and respiratory function at rest and during progressive cycle ergometer exercise in adolescents within 10 days of sport-related concussion compared with non-concussed athletes.<h4>Methods</h4>Concussed participants (n = 26, 15.4 ± 1.1 years, 54% male, 7.3 ± 1.8 days from injury) and control participants (n = 24, 15.8 ± 1.6 years, 58% male) performed the Buffalo Concussion Bike Test. Blood pressure, heart rate, stroke volume, cardiac output, respiratory rate, minute ventilation, oxygen consumption, and end-tidal CO<sub>2</sub> w"],"journal":["Sports medicine (Auckland, N.Z.)"],"pubmed_title":["Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion."],"pmcid":["PMC12913255"],"funding_grant_id":["1R01NS094444","UL1TR001412"],"pubmed_authors":["Johnson BD","Nazir MSZ","Haider MN","Chizuk HM","Leddy JJ","Worts P","Willer BS"],"additional_accession":[]},"is_claimable":false,"name":"Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion.","description":"<h4>Background</h4>Symptom-limited exercise intolerance is a physiological sign of sport-related concussion. Possible etiologies include rest-induced aerobic deconditioning and/or impaired cardiopulmonary function.<h4>Objective</h4>This study examined cardiovascular and respiratory function at rest and during progressive cycle ergometer exercise in adolescents within 10 days of sport-related concussion compared with non-concussed athletes.<h4>Methods</h4>Concussed participants (n = 26, 15.4 ± 1.1 years, 54% male, 7.3 ± 1.8 days from injury) and control participants (n = 24, 15.8 ± 1.6 years, 58% male) performed the Buffalo Concussion Bike Test. Blood pressure, heart rate, stroke volume, cardiac output, respiratory rate, minute ventilation, oxygen consumption, and end-tidal CO<sub>2</sub> w","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T06:54:29.871Z","creation":"2026-07-09T10:43:08.258Z"},"accession":"S-EPMC12913255","cross_references":{"pubmed":["40858863"],"doi":["10.1007/s40279-025-02301-7"]}}