biostudies-literatureLeddy JJNational Center for Advancing Translational SciencesNational Institute of Neurological Disorders and StrokeNCATS NIH HHSNINDS NIH HHS271-282https://www.ebi.ac.uk/biostudies/studies/S-EPMC12913255biostudies-literatureUnknown56(1)<h4>Background</h4>Symptom-limited exercise intolerance is a physiological sign of sport-related concussion. Possible etiologies include rest-induced aerobic deconditioning and/or impaired cardiopulmonary function.<h4>Objective</h4>This study examined cardiovascular and respiratory function at rest and during progressive cycle ergometer exercise in adolescents within 10 days of sport-related concussion compared with non-concussed athletes.<h4>Methods</h4>Concussed participants (n = 26, 15.4 ± 1.1 years, 54% male, 7.3 ± 1.8 days from injury) and control participants (n = 24, 15.8 ± 1.6 years, 58% male) performed the Buffalo Concussion Bike Test. Blood pressure, heart rate, stroke volume, cardiac output, respiratory rate, minute ventilation, oxygen consumption, and end-tidal CO₂ wSports medicine (Auckland, N.Z.)Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion.PMC129132551R01NS094444UL1TR001412Johnson BDNazir MSZHaider MNChizuk HMLeddy JJWorts PWiller BSfalseCardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion.<h4>Background</h4>Symptom-limited exercise intolerance is a physiological sign of sport-related concussion. Possible etiologies include rest-induced aerobic deconditioning and/or impaired cardiopulmonary function.<h4>Objective</h4>This study examined cardiovascular and respiratory function at rest and during progressive cycle ergometer exercise in adolescents within 10 days of sport-related concussion compared with non-concussed athletes.<h4>Methods</h4>Concussed participants (n = 26, 15.4 ± 1.1 years, 54% male, 7.3 ± 1.8 days from injury) and control participants (n = 24, 15.8 ± 1.6 years, 58% male) performed the Buffalo Concussion Bike Test. Blood pressure, heart rate, stroke volume, cardiac output, respiratory rate, minute ventilation, oxygen consumption, and end-tidal CO₂ w2026-01-01T00:00:00Z2026 Jan2026-07-16T06:54:29.871Z2026-07-09T10:43:08.258ZS-EPMC129132554085886310.1007/s40279-025-02301-7