{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(1)"],"submitter":["Zhang W"],"pubmed_abstract":["Tea plants possess a highly heterozygous genome and produce diverse beneficial metabolites, yet the genomic basis of its metabolic diversity remains fully elusive. Here, we show that single-cell sequencing of 107 sperm cells, combined with PacBio HiFi and ONT ultra-long sequencing, enables an accurate haplotype-resolved genome assembly of Fuding Dabaicha (FDDB). Structural variations (SVs) between the two haplotypes comprise 23.8% of the genome and strongly influence crossover patterns. Using these phased genomes, we establish a half-sib-based QTL mapping platform and identify a Gypsy LTR insertion in the promoter of CsDFRb, which associated with the increasing of p-coumaroylquinate levels in young leaves. Moreover, mGWAS reveals 2649 additional loci associated with 2837 metabolites when u"],"journal":["Nature communications"],"pagination":["1754"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12913673"],"repository":["biostudies-literature"],"pubmed_title":["The Camellia sinensis var. sinensis cv. Fuding Dabaicha genome unveils structural variation-driven metabolic innovation."],"pmcid":["PMC12913673"],"pubmed_authors":["Zhang W","Fernie AR","Jiang X","Tariq A","Zhang X","Buchmann J","Luo S","Usadel B","Wen W","Gao D"],"additional_accession":[]},"is_claimable":false,"name":"The Camellia sinensis var. sinensis cv. Fuding Dabaicha genome unveils structural variation-driven metabolic innovation.","description":"Tea plants possess a highly heterozygous genome and produce diverse beneficial metabolites, yet the genomic basis of its metabolic diversity remains fully elusive. Here, we show that single-cell sequencing of 107 sperm cells, combined with PacBio HiFi and ONT ultra-long sequencing, enables an accurate haplotype-resolved genome assembly of Fuding Dabaicha (FDDB). Structural variations (SVs) between the two haplotypes comprise 23.8% of the genome and strongly influence crossover patterns. Using these phased genomes, we establish a half-sib-based QTL mapping platform and identify a Gypsy LTR insertion in the promoter of CsDFRb, which associated with the increasing of p-coumaroylquinate levels in young leaves. Moreover, mGWAS reveals 2649 additional loci associated with 2837 metabolites when u","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T06:52:09.038Z","creation":"2026-07-09T10:42:18.628Z"},"accession":"S-EPMC12913673","cross_references":{"pubmed":["41535305"],"doi":["10.1038/s41467-026-68463-8"]}}