{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hamdan F"],"funding":["European Research Council","Jane ja Aatos Erkon Säätiö","Jane ja Aatos Erkon Säätiö (Jane and Aatos Erkko Foundation)"],"pagination":["1757"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12914026"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Colorectal cancer (CRC) remains refractory to most immunotherapies, with cancer vaccines failing due to an immunosuppressive tumor microenvironment. Here, we show that β-glucan-induced trained immunity overcomes these barriers by reprogramming macrophages through H3K4me3-dependent epigenetic modifications and metabolic rewiring. In female mice vaccinated with peptide-coated adenovirus-based vaccine PeptiCrad, training enhances glycolysis with creatine metabolism sustaining CXCL9/10 production, enabling macrophages to recruit NK cells via CXCR3. In turn, NK cells produce CCL5, driving cDC1 infiltration and antigen presentation, which together amplify effector memory CD8⁺ T cell responses. Moreover, with human peripheral blood mononuclear cells and CRC patient-derived organoids, trained macr"],"journal":["Nature communications"],"pubmed_title":["Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response."],"pmcid":["PMC12914026"],"funding_grant_id":["4705796","681219"],"pubmed_authors":["Hamdan F","D'Alessio F","Giannoula Y","Nieminen AI","Sakalauskaite M","Gandolfi S","Stigzelius V","Seppala TT","Russo S","Izci O","Cerullo V","Napolano A","Alanen KM","Zaghen E","Antignani G","Bottega P","Feodoroff M","Sandberg J","Zambrano N","Gronholm M","Chiaro J","Mustjoki S","Fusciello M","Eriksson O","Kolikova J"],"additional_accession":[]},"is_claimable":false,"name":"Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response.","description":"Colorectal cancer (CRC) remains refractory to most immunotherapies, with cancer vaccines failing due to an immunosuppressive tumor microenvironment. Here, we show that β-glucan-induced trained immunity overcomes these barriers by reprogramming macrophages through H3K4me3-dependent epigenetic modifications and metabolic rewiring. In female mice vaccinated with peptide-coated adenovirus-based vaccine PeptiCrad, training enhances glycolysis with creatine metabolism sustaining CXCL9/10 production, enabling macrophages to recruit NK cells via CXCR3. In turn, NK cells produce CCL5, driving cDC1 infiltration and antigen presentation, which together amplify effector memory CD8⁺ T cell responses. Moreover, with human peripheral blood mononuclear cells and CRC patient-derived organoids, trained macr","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T06:32:47.155Z","creation":"2026-07-09T10:39:39.129Z"},"accession":"S-EPMC12914026","cross_references":{"pubmed":["41605920"],"doi":["10.1038/s41467-026-68466-5"]}}