{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rankine LJ"],"funding":["NHLBI NIH HHS","National Institutes of Health","National Science Foundation"],"pagination":["216-228"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12914451"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(1)"],"pubmed_abstract":["<h4>Purpose</h4>Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured.<h4>Methods and materials</h4>Ten patients receiving conventional radiation therapy (RT) for lung cancer underwent pre-RT and 3-month post-RT magnetic resonance imaging (MRI) using an established hyperpolarized <sup>129</sup>Xe gas exchange technique to map lung function. Four patients underwent an additional 8-month post-RT MRI. The MR signal from inhaled xenon was measured in the following 3 pulmonary compartments: the lung airspaces, the alveolar membrane tissue, and the pulmonary capillaries (interacting with red blood cells [RBCs]). Thoracic <sup>1</sup>H MRI scans were acquired, and "],"journal":["International journal of radiation oncology, biology, physics"],"pubmed_title":["Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized &lt;sup&gt;129&lt;/sup&gt;Xe Gas Exchange Magnetic Resonance Imaging."],"pmcid":["PMC12914451"],"funding_grant_id":["GRFP DGE-1644868","R01 HL105643"],"pubmed_authors":["Kelsey CR","Rankine LJ","Lu J","Das SK","Marks LB","Wang Z","Driehuys B"],"additional_accession":[]},"is_claimable":false,"name":"Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized &lt;sup&gt;129&lt;/sup&gt;Xe Gas Exchange Magnetic Resonance Imaging.","description":"<h4>Purpose</h4>Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured.<h4>Methods and materials</h4>Ten patients receiving conventional radiation therapy (RT) for lung cancer underwent pre-RT and 3-month post-RT magnetic resonance imaging (MRI) using an established hyperpolarized <sup>129</sup>Xe gas exchange technique to map lung function. Four patients underwent an additional 8-month post-RT MRI. The MR signal from inhaled xenon was measured in the following 3 pulmonary compartments: the lung airspaces, the alveolar membrane tissue, and the pulmonary capillaries (interacting with red blood cells [RBCs]). Thoracic <sup>1</sup>H MRI scans were acquired, and ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-07-16T06:37:06.647Z","creation":"2026-07-09T10:40:29.99Z"},"accession":"S-EPMC12914451","cross_references":{"pubmed":["38452858"],"doi":["10.1016/j.ijrobp.2024.02.049"]}}