biostudies-literatureRankine LJNHLBI NIH HHSNational Institutes of HealthNational Science Foundation216-228https://www.ebi.ac.uk/biostudies/studies/S-EPMC12914451biostudies-literatureUnknown120(1)<h4>Purpose</h4>Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured.<h4>Methods and materials</h4>Ten patients receiving conventional radiation therapy (RT) for lung cancer underwent pre-RT and 3-month post-RT magnetic resonance imaging (MRI) using an established hyperpolarized ¹²⁹Xe gas exchange technique to map lung function. Four patients underwent an additional 8-month post-RT MRI. The MR signal from inhaled xenon was measured in the following 3 pulmonary compartments: the lung airspaces, the alveolar membrane tissue, and the pulmonary capillaries (interacting with red blood cells [RBCs]). Thoracic ¹H MRI scans were acquired, and International journal of radiation oncology, biology, physicsQuantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized &lt;sup&gt;129&lt;/sup&gt;Xe Gas Exchange Magnetic Resonance Imaging.PMC12914451GRFP DGE-1644868R01 HL105643Kelsey CRRankine LJLu JDas SKMarks LBWang ZDriehuys BfalseQuantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized &lt;sup&gt;129&lt;/sup&gt;Xe Gas Exchange Magnetic Resonance Imaging.<h4>Purpose</h4>Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured.<h4>Methods and materials</h4>Ten patients receiving conventional radiation therapy (RT) for lung cancer underwent pre-RT and 3-month post-RT magnetic resonance imaging (MRI) using an established hyperpolarized ¹²⁹Xe gas exchange technique to map lung function. Four patients underwent an additional 8-month post-RT MRI. The MR signal from inhaled xenon was measured in the following 3 pulmonary compartments: the lung airspaces, the alveolar membrane tissue, and the pulmonary capillaries (interacting with red blood cells [RBCs]). Thoracic ¹H MRI scans were acquired, and 2024-01-01T00:00:00Z2024 Sep2026-07-16T06:37:06.647Z2026-07-09T10:40:29.99ZS-EPMC129144513845285810.1016/j.ijrobp.2024.02.049