biostudies-literatureUnknown9(2)Huang Z<h4>Importance</h4>Associations between chronic kidney disease (CKD) severity and incident cognitive impairment have not been evaluated in a cohort of patients with CKD.<h4>Objective</h4>To investigate associations between CKD severity, based on the estimated glomerular filtration rate (eGFR) and urinary protein to creatinine ratio (UPCR), and incident cognitive impairment in a cohort of patients with CKD.<h4>Design, setting, and participants</h4>This cohort study investigated 5607 participants with CKD from the ongoing Chronic Renal Insufficiency Cohort (CRIC) Study who were enrolled between 2003 to 2008 and 2013 to 2015. Statistical analysis was conducted from August 2024 to December 2025.<h4>Exposure</h4>Estimated glomerular filtration rate and UPCR.<h4>Main outcomes and measures</h4>GlJAMA network opene2559834https://www.ebi.ac.uk/biostudies/studies/S-EPMC12914485biostudies-literatureChronic Kidney Disease Severity and Risk of Cognitive Impairment.PMC12914485Rao PJaar BGUnruh MLSrivastava AGo ASRao PSDember LMLash JPKiryluk KAnderson AHWeir MRShah VOKurella Tamura MPan YLi CHe JChen JTaliercio JJMills KTSun XRahman MChronic Renal Insufficiency Cohort (CRIC) Study InvestigatorsAppel LJHuang ZYaffe KHan HBazzano LAKelly TNXiao CRicardo ACCohen DLfalseChronic Kidney Disease Severity and Risk of Cognitive Impairment.<h4>Importance</h4>Associations between chronic kidney disease (CKD) severity and incident cognitive impairment have not been evaluated in a cohort of patients with CKD.<h4>Objective</h4>To investigate associations between CKD severity, based on the estimated glomerular filtration rate (eGFR) and urinary protein to creatinine ratio (UPCR), and incident cognitive impairment in a cohort of patients with CKD.<h4>Design, setting, and participants</h4>This cohort study investigated 5607 participants with CKD from the ongoing Chronic Renal Insufficiency Cohort (CRIC) Study who were enrolled between 2003 to 2008 and 2013 to 2015. Statistical analysis was conducted from August 2024 to December 2025.<h4>Exposure</h4>Estimated glomerular filtration rate and UPCR.<h4>Main outcomes and measures</h4>Gl2026-01-01T00:00:00Z2026 Feb2026-07-16T06:41:18.244Z2026-07-09T10:41:16.822ZS-EPMC129144854170149410.1001/jamanetworkopen.2025.59834