{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Melicher F"],"funding":["Grantová Agentura České Republiky","CALIPSOplus","Ministerstvo Školství, Mládeže a Tělovýchovy"],"pagination":["1168-1190"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12914763"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["293(4)"],"pubmed_abstract":["Photorhabdus bacteria live in mutualistic relationships with Heterorhabditis nematodes, and together, they act as effective insect pathogens. These bacteria produce a diverse array of lectins, sugar-binding proteins that are believed to play crucial roles in the complex tripartite interaction among Photorhabdus, nematodes, and their insect hosts. One such lectin, Photorhabdus laumondii tumor necrosis factor (TNF)-like lectin (PLTL), identified in Photorhabdus laumondii subsp. laumondii TTO1, exhibits notable sequence similarity to the N-terminal domain of the BC2L-C lectin (BC2L-CN), a TNF-like lectin recognized for its specificity toward fucosylated glycans associated with human embryonic stem cells and certain cancers. Through glycan array analysis and surface plasmon resonance, we ident"],"journal":["The FEBS journal"],"pubmed_title":["Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor-like lectin."],"pmcid":["PMC12914763"],"funding_grant_id":["730872","21‐29622S","LM2023042","21-29622S"],"pubmed_authors":["Melicher F","Dobes P","Wimmerova M","Faltinek L","Sykorova P","Komarek J","Korsak M","Houser J"],"additional_accession":[]},"is_claimable":false,"name":"Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor-like lectin.","description":"Photorhabdus bacteria live in mutualistic relationships with Heterorhabditis nematodes, and together, they act as effective insect pathogens. These bacteria produce a diverse array of lectins, sugar-binding proteins that are believed to play crucial roles in the complex tripartite interaction among Photorhabdus, nematodes, and their insect hosts. One such lectin, Photorhabdus laumondii tumor necrosis factor (TNF)-like lectin (PLTL), identified in Photorhabdus laumondii subsp. laumondii TTO1, exhibits notable sequence similarity to the N-terminal domain of the BC2L-C lectin (BC2L-CN), a TNF-like lectin recognized for its specificity toward fucosylated glycans associated with human embryonic stem cells and certain cancers. Through glycan array analysis and surface plasmon resonance, we ident","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T06:51:21.961Z","creation":"2026-07-09T10:41:12.762Z"},"accession":"S-EPMC12914763","cross_references":{"pubmed":["41105922"],"doi":["10.1111/febs.70293"]}}