{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li J"],"funding":["key R&D program of department of science and technology of Hubei province, China","Non-profit Central Research Institute Fund of Chinese","Hubei Province Science Fund for Distinguished Young Scholars","Hubei Provincial Department of Science and Technology, Hubei Provincial Key Research and Development Program","National Natural Science Foundation of China"],"pagination":["e20518"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12915110"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(10)"],"pubmed_abstract":["Tissue-resident memory T cells (T<sub>RM</sub>), which function against tumors, infections, and non-self antigens in organ transplantation, exhibit both effector and memory functionality. However, the homeostasis and differentiation of T<sub>RM</sub> is not clear. Using a murine kidney transplant model for long-term observation, our single-cell and spatial transcriptomics showed that CD49a<sup>+</sup>PD1<sup>hi</sup> CD8<sup>+</sup> T<sub>RM</sub> exhibited an effector phenotype with enhanced cytotoxicity at a later stage. This subset might mature from a CXCR6<sup>hi</sup> precursor-like state with proliferation capacity in tertiary lymphoid structures (TLSs) in allografts. Mechanically, BHLHE40 is required for CD49a<sup>+</sup>PD1<sup>hi</sup> CD8<sup>+</sup> T<sub>RM</sub> differentiatio"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["BHLHE40 Orchestrates Effector Tissue-Resident Memory CD8&lt;sup&gt;+&lt;/sup&gt; T Cells and Limits Long-Term Survival of Kidney Graft."],"pmcid":["PMC12915110"],"funding_grant_id":["82471810","82371794","2023BCB013","82271807","2023-PT320-07","2022CFA057","2022BCA015"],"pubmed_authors":["Liu J","Li J","Pan T","Chen Z","Lan P","Yang B","Ma Z","Tang D","Zhou X","Xie B"],"additional_accession":[]},"is_claimable":false,"name":"BHLHE40 Orchestrates Effector Tissue-Resident Memory CD8&lt;sup&gt;+&lt;/sup&gt; T Cells and Limits Long-Term Survival of Kidney Graft.","description":"Tissue-resident memory T cells (T<sub>RM</sub>), which function against tumors, infections, and non-self antigens in organ transplantation, exhibit both effector and memory functionality. However, the homeostasis and differentiation of T<sub>RM</sub> is not clear. Using a murine kidney transplant model for long-term observation, our single-cell and spatial transcriptomics showed that CD49a<sup>+</sup>PD1<sup>hi</sup> CD8<sup>+</sup> T<sub>RM</sub> exhibited an effector phenotype with enhanced cytotoxicity at a later stage. This subset might mature from a CXCR6<sup>hi</sup> precursor-like state with proliferation capacity in tertiary lymphoid structures (TLSs) in allografts. Mechanically, BHLHE40 is required for CD49a<sup>+</sup>PD1<sup>hi</sup> CD8<sup>+</sup> T<sub>RM</sub> differentiatio","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T06:51:51.721Z","creation":"2026-07-09T10:41:24.828Z"},"accession":"S-EPMC12915110","cross_references":{"pubmed":["41486507"],"doi":["10.1002/advs.202520518"]}}