{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yue Y"],"funding":["Shandong Provincial Postdoctoral Science Foundation","Taishan Industrial Experts Programme","National Natural Science Foundation of China","Qingdao Postdoctoral Science Foundation","Postdoctoral Fellowship Program of CPSF"],"pagination":["e0182425"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12915355"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["92(2)"],"pubmed_abstract":["Despite the promise of phages as antibiotic alternatives, their efficacy is often undermined by the rapid emergence of bacterial resistance. Phage-derived enzymes, particularly depolymerases, offer a compelling strategy to overcome this limitation and enhance antibacterial therapy. Focusing on <i>Vibrio</i> pathogens, the major threats to global aquaculture, our bioinformatic analysis revealed that 79.4% of cultured and 46.2% of uncultured <i>Vibrio</i> phages encode putative depolymerases, underscoring a vast but underexploited antibacterial resource. We further isolated and characterized VnaP, a depolymerase-encoding phage (novel genus, <i>Caudovircetes</i>) that forms distinctive halo plaques indicative of depolymerase activity. Genome analysis identified ORF193, encoding a novel polysa"],"journal":["Applied and environmental microbiology"],"pubmed_title":["Mining a vibriophage depolymerase for enhanced pathogen control in aquaculture."],"pmcid":["PMC12915355"],"funding_grant_id":["42476115","SDCX-ZG-202400186","42576102","GZC20232809","QDBSH20240102185","tscy2024116","42206124","42406120"],"pubmed_authors":["He Y","Li C","Zhang Y","Yin R","Zhao J","Wang Z","Yue Y"],"additional_accession":[]},"is_claimable":false,"name":"Mining a vibriophage depolymerase for enhanced pathogen control in aquaculture.","description":"Despite the promise of phages as antibiotic alternatives, their efficacy is often undermined by the rapid emergence of bacterial resistance. Phage-derived enzymes, particularly depolymerases, offer a compelling strategy to overcome this limitation and enhance antibacterial therapy. Focusing on <i>Vibrio</i> pathogens, the major threats to global aquaculture, our bioinformatic analysis revealed that 79.4% of cultured and 46.2% of uncultured <i>Vibrio</i> phages encode putative depolymerases, underscoring a vast but underexploited antibacterial resource. We further isolated and characterized VnaP, a depolymerase-encoding phage (novel genus, <i>Caudovircetes</i>) that forms distinctive halo plaques indicative of depolymerase activity. Genome analysis identified ORF193, encoding a novel polysa","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T06:38:40.269Z","creation":"2026-07-09T10:39:56.188Z"},"accession":"S-EPMC12915355","cross_references":{"pubmed":["41524417"],"doi":["10.1128/aem.01824-25"]}}