{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["Natural Science Foundation of Hubei Province","Guangxi Innovation-Driven Development Project","Major Project of Scientific Research and Technology Journal of Development Plan of Nanning","National Natural Science Foundation of China","Guangxi Key Research and Development Program","Natural Science Foundation of Guangxi Zhuang Autonomous Region"],"pagination":["146-154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12915376"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(2)"],"pubmed_abstract":["Background
Adrenocortical hormones, particularly 11-oxygenated androgens, are pivotal in female reproductive health and fertility. Standardized detection kits and population-specific reference intervals are lacking in China, hindering related clinical applications.Methods
A HPLC-tandem mass spectrometry (HPLC-MS/MS) pipeline was developed, rigorously validated, and applied to simultaneously quantify corticosterone, cortisone, cortisol, 18-OH cortisol, androstenedione (A4), 11β-hydroxyandrostenedione (11-OH A4), dehydroepiandrosterone, and dehydroepiandrosterone sulfate in serum samples from 455 reproductive-aged women (18-45 yrs) in Guangxi, China. Age-dependent concentration trends were analyzed, and reference intervals stratified by age (2.5th to 97.5th percentiles) were "],"journal":["Annals of laboratory medicine"],"pubmed_title":["Development and Validation of a High-performance Liquid Chromatography-Tandem Mass Spectrometry Method for Detecting Adrenocortical Hormones and Establishment of Age-stratified Reference Intervals in Reproductive-aged Women from Guangxi, China."],"pmcid":["PMC12915376"],"funding_grant_id":["AA18118016","82270806","82460851","GuikeAA22398","20221023","82460160","GuikeAA22412","2020GXNSFDA297024","2021JJA140912","2024AFB776","GuikeAB21196022","2024GXNFSBA010192","AB22035080"],"pubmed_authors":["Deng S","Jiang J","Li J","Jin T","Qin X","Wang G","Ye Y","Wei Y","Wu F","Huang P","Jiang Y","Liu Y","Zheng J","Huang S","Long Y","Mo Z","Nong Y","Yan B"],"additional_accession":[]},"is_claimable":false,"name":"Development and Validation of a High-performance Liquid Chromatography-Tandem Mass Spectrometry Method for Detecting Adrenocortical Hormones and Establishment of Age-stratified Reference Intervals in Reproductive-aged Women from Guangxi, China.","description":"Background
Adrenocortical hormones, particularly 11-oxygenated androgens, are pivotal in female reproductive health and fertility. Standardized detection kits and population-specific reference intervals are lacking in China, hindering related clinical applications.Methods
A HPLC-tandem mass spectrometry (HPLC-MS/MS) pipeline was developed, rigorously validated, and applied to simultaneously quantify corticosterone, cortisone, cortisol, 18-OH cortisol, androstenedione (A4), 11β-hydroxyandrostenedione (11-OH A4), dehydroepiandrosterone, and dehydroepiandrosterone sulfate in serum samples from 455 reproductive-aged women (18-45 yrs) in Guangxi, China. Age-dependent concentration trends were analyzed, and reference intervals stratified by age (2.5th to 97.5th percentiles) were ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-16T06:58:37.189Z","creation":"2026-07-09T10:41:28.215Z"},"accession":"S-EPMC12915376","cross_references":{"pubmed":["40987612"],"doi":["10.3343/alm.2025.0090"]}}