{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amir CM"],"funding":["NIDA NIH HHS","National Institutes of Health","National Institute on Drug Abuse"],"pagination":["165-174"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12915486"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(2)"],"pubmed_abstract":["<h4>Background</h4>Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship. We aim to elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences (PLEs) by probing correlates of reward anticipation, a neurobehavioral marker of endocannabinoid-mediated dopaminergic function.<h4>Methods</h4>This longitudinal, prospective study analyzed task-related functional neuroimaging data from baseline (N = 11,368), 2-year follow-up (n = 7928), and 4-year follow-up (n = 2982) of the ongoing ABCD (Adolescent Brain Cognitive Development) Study, which recruited children ages 9 to 10 years at baseline from"],"journal":["Biological psychiatry"],"pubmed_title":["Altered Neurobehavioral Reward Response Predicts Psychotic-Like Experiences in Youth Exposed to Cannabis Prenatally."],"pmcid":["PMC12915486"],"funding_grant_id":["U01DA041106","U01DA041028","U01DA041148","U01DA041048","U01DA041025","U01DA041089","U01DA041022","U01DA041120","U01DA050987","U01DA050988","U01DA050989","U01DA051039","U01DA051038","U01DA051016","U01DA051018","U01DA051037","F31DA060068","U01DA041117","U24DA041147","U24DA041123","U01DA041134","U01DA041156","U01DA041174","F31 DA060068","U01DA041093"],"pubmed_authors":["Cooper ZD","Ghahremani DG","Amir CM","Bearden CE","Chang SE"],"additional_accession":[]},"is_claimable":false,"name":"Altered Neurobehavioral Reward Response Predicts Psychotic-Like Experiences in Youth Exposed to Cannabis Prenatally.","description":"<h4>Background</h4>Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship. We aim to elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences (PLEs) by probing correlates of reward anticipation, a neurobehavioral marker of endocannabinoid-mediated dopaminergic function.<h4>Methods</h4>This longitudinal, prospective study analyzed task-related functional neuroimaging data from baseline (N = 11,368), 2-year follow-up (n = 7928), and 4-year follow-up (n = 2982) of the ongoing ABCD (Adolescent Brain Cognitive Development) Study, which recruited children ages 9 to 10 years at baseline from","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T06:40:15.893Z","creation":"2026-07-09T10:40:28.758Z"},"accession":"S-EPMC12915486","cross_references":{"pubmed":["40466988"],"doi":["10.1016/j.biopsych.2025.05.019"]}}