biostudies-literatureAmir CMNIDA NIH HHSNational Institutes of HealthNational Institute on Drug Abuse165-174https://www.ebi.ac.uk/biostudies/studies/S-EPMC12915486biostudies-literatureUnknown99(2)<h4>Background</h4>Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship. We aim to elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences (PLEs) by probing correlates of reward anticipation, a neurobehavioral marker of endocannabinoid-mediated dopaminergic function.<h4>Methods</h4>This longitudinal, prospective study analyzed task-related functional neuroimaging data from baseline (N = 11,368), 2-year follow-up (n = 7928), and 4-year follow-up (n = 2982) of the ongoing ABCD (Adolescent Brain Cognitive Development) Study, which recruited children ages 9 to 10 years at baseline fromBiological psychiatryAltered Neurobehavioral Reward Response Predicts Psychotic-Like Experiences in Youth Exposed to Cannabis Prenatally.PMC12915486U01DA041106U01DA041028U01DA041148U01DA041048U01DA041025U01DA041089U01DA041022U01DA041120U01DA050987U01DA050988U01DA050989U01DA051039U01DA051038U01DA051016U01DA051018U01DA051037F31DA060068U01DA041117U24DA041147U24DA041123U01DA041134U01DA041156U01DA041174F31 DA060068U01DA041093Cooper ZDGhahremani DGAmir CMBearden CEChang SEfalseAltered Neurobehavioral Reward Response Predicts Psychotic-Like Experiences in Youth Exposed to Cannabis Prenatally.<h4>Background</h4>Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship. We aim to elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences (PLEs) by probing correlates of reward anticipation, a neurobehavioral marker of endocannabinoid-mediated dopaminergic function.<h4>Methods</h4>This longitudinal, prospective study analyzed task-related functional neuroimaging data from baseline (N = 11,368), 2-year follow-up (n = 7928), and 4-year follow-up (n = 2982) of the ongoing ABCD (Adolescent Brain Cognitive Development) Study, which recruited children ages 9 to 10 years at baseline from2026-01-01T00:00:00Z2026 Jan2026-07-16T06:40:15.893Z2026-07-09T10:40:28.758ZS-EPMC129154864046698810.1016/j.biopsych.2025.05.019