biostudies-literatureUnknown19(2)Ricciardi MJ<h4>Background</h4>Atrial secondary mitral regurgitation (aSMR) is a distinct subtype of SMR characterized by normal leaflets, annular dilatation, left atrial (LA) enlargement, and preserved left ventricular function. Treatment pathways for aSMR are undefined, and limited data exist regarding outcomes following mitral transcatheter edge-to-edge repair (MTEER). The analysis aimed to evaluate outcomes in patients with aSMR treated with MTEER from the EXPANDed (Evaluation of the MitraClip X System Post-MArket Real-World CliNical Outcomes Database ) studies.<h4>Methods</h4>One-year outcomes were assessed in patients from the EXPANDed studies (EXPAND and EXPAND G4 [Evaluation of the MitraClip X System Post-MArket Real-World CliNical Outcomes Database Generation 4 ]) who met criteria for aSMR. aCirculation. Cardiovascular interventionse015883https://www.ebi.ac.uk/biostudies/studies/S-EPMC12915549biostudies-literatureAtrial Secondary Mitral Regurgitation Outcomes Following Mitral Transcatheter Edge-to-Edge Repair: Results From the EXPANDed Studies.PMC12915549Mahoney PMorse MAMKar SRinaldi MJvon Bardeleben RSAsch FMZamorano JRogers JHPrice MJDong MRodriguez ERuf THuang RSingh GRottbauer WRicciardi MJDenti PMaisano FChehab BHorn PfalseAtrial Secondary Mitral Regurgitation Outcomes Following Mitral Transcatheter Edge-to-Edge Repair: Results From the EXPANDed Studies.<h4>Background</h4>Atrial secondary mitral regurgitation (aSMR) is a distinct subtype of SMR characterized by normal leaflets, annular dilatation, left atrial (LA) enlargement, and preserved left ventricular function. Treatment pathways for aSMR are undefined, and limited data exist regarding outcomes following mitral transcatheter edge-to-edge repair (MTEER). The analysis aimed to evaluate outcomes in patients with aSMR treated with MTEER from the EXPANDed (Evaluation of the MitraClip X System Post-MArket Real-World CliNical Outcomes Database ) studies.<h4>Methods</h4>One-year outcomes were assessed in patients from the EXPANDed studies (EXPAND and EXPAND G4 [Evaluation of the MitraClip X System Post-MArket Real-World CliNical Outcomes Database Generation 4 ]) who met criteria for aSMR. a2026-01-01T00:00:00Z2026 Feb2026-07-16T06:32:38.315Z2026-07-09T10:39:32.571ZS-EPMC129155494156213610.1161/CIRCINTERVENTIONS.125.015883