{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31(3)"],"submitter":["Puigseslloses P"],"pubmed_abstract":["Current first-line antidepressants, such as selective serotonin reuptake inhibitors (SSRI), often present a delayed onset of action and fail to effectively treat a large proportion of patients, leaving a gap in the treatment of mood disorders. Psychedelics have recently emerged as promising alternatives due to their ability to produce fast-acting antidepressant effects through neuroplastic adaptations, but their hallucinogenic properties remain a major obstacle to their widespread therapeutic use. In this study, we characterized a novel class of halogenated DMT derivatives-5-F-DMT, 5-Cl-DMT, and 5-Br-DMT-for their pharmacological activity, behavioral effects, and therapeutic potential. Using a combination of in vitro assays, in silico modeling, and in vivo behavioral and gene expression st"],"journal":["Molecular psychiatry"],"pagination":["1733-1745"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12916285"],"repository":["biostudies-literature"],"pubmed_title":["Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential."],"pmcid":["PMC12916285"],"pubmed_authors":["Escubedo E","Pablo-Quesada A","Puigseslloses P","Lopez-Arnau R","Ortigosa JR","Berzosa X","Modenutti CP","Stove C","Nadal-Gratacos N","Pottie E","Fumas B","Pubill D","Riera-Colomer C","Ettcheto M"],"additional_accession":[]},"is_claimable":false,"name":"Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential.","description":"Current first-line antidepressants, such as selective serotonin reuptake inhibitors (SSRI), often present a delayed onset of action and fail to effectively treat a large proportion of patients, leaving a gap in the treatment of mood disorders. Psychedelics have recently emerged as promising alternatives due to their ability to produce fast-acting antidepressant effects through neuroplastic adaptations, but their hallucinogenic properties remain a major obstacle to their widespread therapeutic use. In this study, we characterized a novel class of halogenated DMT derivatives-5-F-DMT, 5-Cl-DMT, and 5-Br-DMT-for their pharmacological activity, behavioral effects, and therapeutic potential. Using a combination of in vitro assays, in silico modeling, and in vivo behavioral and gene expression st","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-16T09:14:56.405Z","creation":"2026-07-09T10:46:19.991Z"},"accession":"S-EPMC12916285","cross_references":{"pubmed":["41120735"],"doi":["10.1038/s41380-025-03308-2"]}}