{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi WS"],"funding":["Terry Fox Research Institute Prairie Cancer Research Consortium","Canadian Institutes of Health Research","CIHR"],"pagination":["3072-3086"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12916726"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(12)"],"pubmed_abstract":["<h4>Background</h4>Glioblastoma (GBM) is a deadly brain cancer with a dismal prognosis. There is evidence that infiltration and therapy resistance in GBM are driven by tumor microtubes (TMs), ultra-long membrane-enclosed protrusions that serve as intercellular communication channels. The aims of this study were to investigate the role of TMs and identify the molecular drivers involved in TM formation.<h4>Methods</h4>We used patient-derived GBM neurosphere cultures that produce TMs to investigate TM dynamics, the proteins and pathways involved in TM formation, and the effect of targeting brain fatty acid-binding protein (FABP7) on mouse survival using an orthotopic model of GBM.<h4>Results</h4>The radial glial cell marker, FABP7, is highly expressed in TMs. Like GAP43, FABP7 is critically i"],"journal":["Neuro-oncology"],"pubmed_title":["Glioblastoma tumor microtubes and brain fatty acid-binding protein: Path to directional infiltration."],"pmcid":["PMC12916726"],"funding_grant_id":["190313"],"pubmed_authors":["Yasmin L","Au K","Godbout R","Bukhari AB","Jeon P","Larocque MP","Peyton S","Garg M","Glubrecht DD","Sun X","van Landeghem FKH","Mak C","Goping IS","Githaka JM","Choi WS","McGinn D","Xu X","Liu RZ"],"additional_accession":[]},"is_claimable":false,"name":"Glioblastoma tumor microtubes and brain fatty acid-binding protein: Path to directional infiltration.","description":"<h4>Background</h4>Glioblastoma (GBM) is a deadly brain cancer with a dismal prognosis. There is evidence that infiltration and therapy resistance in GBM are driven by tumor microtubes (TMs), ultra-long membrane-enclosed protrusions that serve as intercellular communication channels. The aims of this study were to investigate the role of TMs and identify the molecular drivers involved in TM formation.<h4>Methods</h4>We used patient-derived GBM neurosphere cultures that produce TMs to investigate TM dynamics, the proteins and pathways involved in TM formation, and the effect of targeting brain fatty acid-binding protein (FABP7) on mouse survival using an orthotopic model of GBM.<h4>Results</h4>The radial glial cell marker, FABP7, is highly expressed in TMs. Like GAP43, FABP7 is critically i","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-16T10:07:42.623Z","creation":"2026-07-09T10:49:03.006Z"},"accession":"S-EPMC12916726","cross_references":{"pubmed":["40891350"],"doi":["10.1093/neuonc/noaf200"]}}