{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Canario R"],"funding":["Universidade do Porto","Swiss National Science Foundation"],"pagination":["309-323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12916920"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["488(2)"],"pubmed_abstract":["Tubo-ovarian high-grade serous carcinoma (HGSC) with proficient homologous recombination (HR) DNA repair (HRP) accounts for approximately 50% of cases and is associated with platinum-resistance and poor prognosis. We hypothesize that the acquisition of hybrid phenotypes displaying both epithelial and mesenchymal (E/M) features may be involved in the malignant transformation and tumour dissemination in this subgroup. Therefore, we analysed, by digital pathology, the expression and prognostic significance of 3 classic cadherins (E-cadherin, epithelial marker; N-cadherin, mesenchymal marker; and P-cadherin, candidate marker of hybrid E/M) in 577 formalin-fixed paraffin-embedded human samples representing the putative stepwise serous carcinogenesis in the Fallopian tube epithelium (FTE). We ob"],"journal":["Virchows Archiv : an international journal of pathology"],"pubmed_title":["P-cadherin overexpression is associated with early transformation of the Fallopian tube epithelium and aggressiveness of tubo-ovarian high-grade serous carcinoma."],"pmcid":["PMC12916920"],"funding_grant_id":["207975"],"pubmed_authors":["Ribeiro AS","Barbosa A","Heinzelmann-Schwarz V","Teixeira MR","Bartosch C","Ricardo S","Santos C","Coelho R","Monteiro P","Lopes P","Peixoto A","Morgado I","Paredes J","Canario R","Mendes N","Jacob F"],"additional_accession":[]},"is_claimable":false,"name":"P-cadherin overexpression is associated with early transformation of the Fallopian tube epithelium and aggressiveness of tubo-ovarian high-grade serous carcinoma.","description":"Tubo-ovarian high-grade serous carcinoma (HGSC) with proficient homologous recombination (HR) DNA repair (HRP) accounts for approximately 50% of cases and is associated with platinum-resistance and poor prognosis. We hypothesize that the acquisition of hybrid phenotypes displaying both epithelial and mesenchymal (E/M) features may be involved in the malignant transformation and tumour dissemination in this subgroup. Therefore, we analysed, by digital pathology, the expression and prognostic significance of 3 classic cadherins (E-cadherin, epithelial marker; N-cadherin, mesenchymal marker; and P-cadherin, candidate marker of hybrid E/M) in 577 formalin-fixed paraffin-embedded human samples representing the putative stepwise serous carcinogenesis in the Fallopian tube epithelium (FTE). We ob","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T09:16:25.982Z","creation":"2026-07-09T10:46:47.667Z"},"accession":"S-EPMC12916920","cross_references":{"pubmed":["40320493"],"doi":["10.1007/s00428-025-04104-7"]}}