{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krisai P"],"funding":["Swiss National Science Foundation"],"pagination":["120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12916941"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["<h4>Background</h4>The interrelationships between atrial fibrillation (AF), brain lesions and cognitive function are poorly understood. We aimed to investigate the relationship of AF with brain lesions and cognition.<h4>Methods</h4>We enrolled 1,480 patients with and 959 without AF in a multicenter prospective study (Swiss-AF; NCT02105844). We assessed brain structure, and cognition using the Montreal Cognitive Assessment (MoCA). Brain magnetic resonance imaging (MRI) was performed to assess large non-cortical and cortical infarcts (LNCCI), small non-cortical infarcts (SNCI), white matter hyperintensities (WMH), and microbleeds. Using causal mediation analyses, we investigated the direct (lesion-independent) and indirect (lesion-mediated) effects of AF on cognition.<h4>Results</h4>Mean age"],"journal":["Communications medicine"],"pubmed_title":["Ischemic brain infarcts, white matter hyperintensities, and cognitive impairment are increased in patients with Atrial Fibrillation."],"pmcid":["PMC12916941"],"funding_grant_id":["148474"],"pubmed_authors":["Ruckli-Kaeppeli A","Frangi-Kultalahti J","Hurbin M","Anesini A","Gret A","Conen D","Shah D","Monsch A","Gallet H","Huber P","Firmann M","Gasser A","Loewe A","Vicari L","Rodondi N","Cereda C","Fischer U","Melchiorre PAM","Coslovsky M","Rigamonti E","Brenner R","Eberli F","Nadler J","Rommers N","Dahlheim L","Monsch AU","Dillier R","Buhler K","Kuest S","Schmid R","Schwab N","Novak J","Bernheim A","Badertscher P","Scheuch K","Young M","Stagliano S","Gemperle M","Lazeyras F","Duering M","Meier S","Roth M","Meier V","Roth J","Kuhne M","Tynan N","Stephan FP","Schlomowitsch F","Villinger J","Sporns P","Aeschbacher S","Liedtke C","Terrot T","Altermatt A","Hennings E","Schneider C","Fluckiger T","Conte G","Bonetti N","Laube E","Baumann C","Meier J","Mehmann B","Ehret G","Regoli F","Juchli I","Kellner-Weldon F","Frick M","Schneider X","Hellrigl S","Fink K","Gallino A","Osswald S","Bonati LH","Jadidi A","Guillermet E","Sticherling C","Feller M","Justi V","Ammann P","Ruberte E","Caputo ML","Berte B","Rime M","Foucras S","Beer JH","Roten L","Grau A","Jung S","Altmann D","Sinnecker T","Simon P","Adam L","Perret P","Valentino MD","Di Valentino M","Schwenkglenks M","Aubert CE","Kobza R","Schmidt K","Ronchi M","Reichlin T","Wiederkehr C","Koch M","Porretta AP","Muller AS","Peronaci R","Paladini RE","Rutz F","Ruckstuhl N","Zuern CS","Russi I","Tavel P","Lauriers N","Meyre PB","Deubelbeiss M","Obst T","Aebersold H","Mahfoud F","Saffari THZ","Kerler R","Thoni A","Zuber V","Zuber P","Aujesky D","Foster F","Girroy C","Wenger R","Weishaupt D","Leuenberger S","Rakovic D","Muller A","Muller C","Schlapfer J","Vollmin G","Auricchio A","Cianfoni A","Peter R","Moutzouri E","During M","Nuoffer A","Neuschwander P","Hofer D","Studerus K","Jeger R","Friedli C","Schweigler A","Pin A","Murugiah S","De Perna ML","Lovblad KO","Carmine D","Wurfel J","Moschovitis G","Hischier D","Franzini C","Ehrsam L","Meyer-Zurn C","Krisai P","eMBA, for the Swiss-AF Investigators","Fuhrer J","Mattle H","Hayoz D","Camporini C","Mean M","Vitelli S","Netzer S","Salzmann S","Blum S","Amann M","Groen C"],"additional_accession":[]},"is_claimable":false,"name":"Ischemic brain infarcts, white matter hyperintensities, and cognitive impairment are increased in patients with Atrial Fibrillation.","description":"<h4>Background</h4>The interrelationships between atrial fibrillation (AF), brain lesions and cognitive function are poorly understood. We aimed to investigate the relationship of AF with brain lesions and cognition.<h4>Methods</h4>We enrolled 1,480 patients with and 959 without AF in a multicenter prospective study (Swiss-AF; NCT02105844). We assessed brain structure, and cognition using the Montreal Cognitive Assessment (MoCA). Brain magnetic resonance imaging (MRI) was performed to assess large non-cortical and cortical infarcts (LNCCI), small non-cortical infarcts (SNCI), white matter hyperintensities (WMH), and microbleeds. Using causal mediation analyses, we investigated the direct (lesion-independent) and indirect (lesion-mediated) effects of AF on cognition.<h4>Results</h4>Mean age","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T10:02:42.675Z","creation":"2026-07-09T10:48:12.653Z"},"accession":"S-EPMC12916941","cross_references":{"pubmed":["41593217"],"doi":["10.1038/s43856-026-01389-w"]}}