biostudies-literatureAusderau KKU.S. Department of Health & Human Services | NIH | National Eye InstituteU.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious DiseasesU.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development1803https://www.ebi.ac.uk/biostudies/studies/S-EPMC12917130biostudies-literatureUnknown17(1)Prenatal Zika virus (ZIKV) exposure can result in outcomes ranging from severe birth defects to subtle developmental delays, yet the underlying mechanisms remain unclear. Using a translational rhesus macaque model, we assess visual, auditory, and neurodevelopmental outcomes through 12 months of age following first-trimester ZIKV inoculation. Pregnant macaques, either flavivirus-naive or with prior dengue virus (DENV) exposure, are inoculated with Asian or African ZIKV lineages. Maternal viremia duration, placental viral burden, and neutralizing antibody titers vary but are not associated with developmental outcomes. At 12 months, ZIKV-exposed infants exhibit altered maternal attachment behaviors and reduced inhibition toward novel sensory stimuli. Visual evoked potentials are impaired at 3Nature communicationsPrenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques.PMC12917130AI153130P50HD105353P30EY016665Kim CFriedrich TCAusderau KKMenna VSun AVer Hoeve JKrabbe NPSimmons HAEckes FCapuano SKatz ASpanton RVWeiler AMBoerigter BBasu PWalsh SRazo ERMohr ELGutkes JMitzey AMKabakov SAliota MTShah ARasmussen CHartman ANork TMDrew JRfalsePrenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques.Prenatal Zika virus (ZIKV) exposure can result in outcomes ranging from severe birth defects to subtle developmental delays, yet the underlying mechanisms remain unclear. Using a translational rhesus macaque model, we assess visual, auditory, and neurodevelopmental outcomes through 12 months of age following first-trimester ZIKV inoculation. Pregnant macaques, either flavivirus-naive or with prior dengue virus (DENV) exposure, are inoculated with Asian or African ZIKV lineages. Maternal viremia duration, placental viral burden, and neutralizing antibody titers vary but are not associated with developmental outcomes. At 12 months, ZIKV-exposed infants exhibit altered maternal attachment behaviors and reduced inhibition toward novel sensory stimuli. Visual evoked potentials are impaired at 32026-01-01T00:00:00Z2026 Jan2026-07-16T09:20:03.687Z2026-07-09T10:46:50.064ZS-EPMC129171304160591810.1038/s41467-026-68517-x