{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(4)"],"submitter":["Ferrant J"],"pubmed_abstract":["<h4>Abstract</h4>Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are the 2 most common B-cell lymphomas and are characterized by a dynamic crosstalk between tumor B cells and a heterogeneous, tumor-supportive microenvironment, such as immune, endothelial, and stromal components. Despite their recognized impact on the pathogenesis and prognosis of B-cell lymphoma, tumor-associated macrophages (TAM) have not been extensively explored in these diseases. In this study, we investigated mononuclear phagocyte (MNP) heterogeneity at the single-cell level and the activation profile of MNP, stromal, and endothelial compartments, in B-cell lymphoma lymph nodes compared to reactive secondary lymphoid organs. This was achieved using a combination of mass cytometry, single-cell RNA se"],"journal":["Blood advances"],"pagination":["1217-1232"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12917531"],"repository":["biostudies-literature"],"pubmed_title":["Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells."],"pmcid":["PMC12917531"],"pubmed_authors":["Hoareau B","Michaud HA","Launay V","Roussel M","Papa I","Pangault C","Van Acker N","Manson G","Deleurme L","Monvoisin C","Padonou F","Albaud B","Llamas Gutierrez F","Tarte K","Leonard S","Bonnefoy N","Ferrant J","Shipp MA","Pecot T","Dubec-Fleury C","Le Gallou S","Barthel A","Laurent C","Brottier C"],"additional_accession":[]},"is_claimable":false,"name":"Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells.","description":"<h4>Abstract</h4>Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are the 2 most common B-cell lymphomas and are characterized by a dynamic crosstalk between tumor B cells and a heterogeneous, tumor-supportive microenvironment, such as immune, endothelial, and stromal components. Despite their recognized impact on the pathogenesis and prognosis of B-cell lymphoma, tumor-associated macrophages (TAM) have not been extensively explored in these diseases. In this study, we investigated mononuclear phagocyte (MNP) heterogeneity at the single-cell level and the activation profile of MNP, stromal, and endothelial compartments, in B-cell lymphoma lymph nodes compared to reactive secondary lymphoid organs. This was achieved using a combination of mass cytometry, single-cell RNA se","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T09:17:52.444Z","creation":"2026-07-09T10:47:00.089Z"},"accession":"S-EPMC12917531","cross_references":{"pubmed":["41061154"],"doi":["10.1182/bloodadvances.2024015689"]}}