{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(6)"],"submitter":["Eisen LS"],"pubmed_abstract":["Trifluoromethylated pyrazoles and their derivatives are of great interest due to their biological and pharmacological relevance. However, efficient methods for their preparation via late-stage trifluoromethylation strategies remain limited. Herein, we report a practical and efficient method for the direct trifluoromethylation of pyrazoles using in situ generated CF<sub>3</sub> radicals and inexpensive copper-(II) salts as catalysts at room temperature. The method exhibits excellent functional group tolerance. DFT studies support the observed reactivity trends and provide insight into the electronic effects governing CF<sub>3</sub> radical addition. This strategy holds promise for the generation of highly substituted pyrazoles of interest in biomedical and crop-science applications."],"journal":["ACS omega"],"pagination":["10664-10673"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12917629"],"repository":["biostudies-literature"],"pubmed_title":["Copper-Mediated Late-Stage Radical Trifluoromethylation of Pyrazole-Type Scaffolds."],"pmcid":["PMC12917629"],"pubmed_authors":["Eisen LS","Mendez M","Griwatz JH","Gomez-Bengoa E","Ruf S"],"additional_accession":[]},"is_claimable":false,"name":"Copper-Mediated Late-Stage Radical Trifluoromethylation of Pyrazole-Type Scaffolds.","description":"Trifluoromethylated pyrazoles and their derivatives are of great interest due to their biological and pharmacological relevance. However, efficient methods for their preparation via late-stage trifluoromethylation strategies remain limited. Herein, we report a practical and efficient method for the direct trifluoromethylation of pyrazoles using in situ generated CF<sub>3</sub> radicals and inexpensive copper-(II) salts as catalysts at room temperature. The method exhibits excellent functional group tolerance. DFT studies support the observed reactivity trends and provide insight into the electronic effects governing CF<sub>3</sub> radical addition. This strategy holds promise for the generation of highly substituted pyrazoles of interest in biomedical and crop-science applications.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T18:03:15.795Z","creation":"2026-07-09T11:10:46.582Z"},"accession":"S-EPMC12917629","cross_references":{"pubmed":["41726639"],"doi":["10.1021/acsomega.5c12212"]}}