{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(6)"],"submitter":["Abul Hasnat M"],"pubmed_abstract":["Chitosan nanoparticle-based drug delivery systems incorporating 4-carboxy-phenylboronic acid (PBA) have emerged as a key strategy for enhancing therapeutic efficacy by active targeting of tumor and improving drug loading capacity. Herein, we have developed a PBA-modified chitosan-based (PBA-CS) semi-interpenetrating polymer network (semi-IPN) nanoparticles (NPs) of 4-carboxy-phenylboronic acid-conjugated chitosan-poly-(1-vinylimidazole) (PBA-CS-PVIm) and 4-carboxy-phenylboronic acid-conjugated chitosan-poly-(methacrylic acid) (PBA-CS-PMAA) via free radical polymerization of 1-vinyl imidazole (VIm) and methacrylic acid (MAA), with high drug loading capacity of doxorubicin (Dox). The synthesized semi-IPN NPs were characterized using Fourier transform infrared spectroscopy (ATR-FTIR), transmi"],"journal":["ACS omega"],"pagination":["9003-9021"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12917645"],"repository":["biostudies-literature"],"pubmed_title":["pH-Responsive Semi-IPN Nanoparticles Based on 4‑Carboxyphenylboronic Acid-Modified Chitosan for Targeted and Controlled Release of Chemotherapeutic Drug."],"pmcid":["PMC12917645"],"pubmed_authors":["Reza MS","Ihara H","Abul Hasnat M","Khan MN","Shikuku R","Takafuji M"],"additional_accession":[]},"is_claimable":false,"name":"pH-Responsive Semi-IPN Nanoparticles Based on 4‑Carboxyphenylboronic Acid-Modified Chitosan for Targeted and Controlled Release of Chemotherapeutic Drug.","description":"Chitosan nanoparticle-based drug delivery systems incorporating 4-carboxy-phenylboronic acid (PBA) have emerged as a key strategy for enhancing therapeutic efficacy by active targeting of tumor and improving drug loading capacity. Herein, we have developed a PBA-modified chitosan-based (PBA-CS) semi-interpenetrating polymer network (semi-IPN) nanoparticles (NPs) of 4-carboxy-phenylboronic acid-conjugated chitosan-poly-(1-vinylimidazole) (PBA-CS-PVIm) and 4-carboxy-phenylboronic acid-conjugated chitosan-poly-(methacrylic acid) (PBA-CS-PMAA) via free radical polymerization of 1-vinyl imidazole (VIm) and methacrylic acid (MAA), with high drug loading capacity of doxorubicin (Dox). The synthesized semi-IPN NPs were characterized using Fourier transform infrared spectroscopy (ATR-FTIR), transmi","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T17:59:13.506Z","creation":"2026-07-09T11:10:18.763Z"},"accession":"S-EPMC12917645","cross_references":{"pubmed":["41726616"],"doi":["10.1021/acsomega.5c04836"]}}