biostudies-literatureUnknown11(6)Abul Hasnat MChitosan nanoparticle-based drug delivery systems incorporating 4-carboxy-phenylboronic acid (PBA) have emerged as a key strategy for enhancing therapeutic efficacy by active targeting of tumor and improving drug loading capacity. Herein, we have developed a PBA-modified chitosan-based (PBA-CS) semi-interpenetrating polymer network (semi-IPN) nanoparticles (NPs) of 4-carboxy-phenylboronic acid-conjugated chitosan-poly-(1-vinylimidazole) (PBA-CS-PVIm) and 4-carboxy-phenylboronic acid-conjugated chitosan-poly-(methacrylic acid) (PBA-CS-PMAA) via free radical polymerization of 1-vinyl imidazole (VIm) and methacrylic acid (MAA), with high drug loading capacity of doxorubicin (Dox). The synthesized semi-IPN NPs were characterized using Fourier transform infrared spectroscopy (ATR-FTIR), transmiACS omega9003-9021https://www.ebi.ac.uk/biostudies/studies/S-EPMC12917645biostudies-literaturepH-Responsive Semi-IPN Nanoparticles Based on 4‑Carboxyphenylboronic Acid-Modified Chitosan for Targeted and Controlled Release of Chemotherapeutic Drug.PMC12917645Reza MSIhara HAbul Hasnat MKhan MNShikuku RTakafuji MfalsepH-Responsive Semi-IPN Nanoparticles Based on 4‑Carboxyphenylboronic Acid-Modified Chitosan for Targeted and Controlled Release of Chemotherapeutic Drug.Chitosan nanoparticle-based drug delivery systems incorporating 4-carboxy-phenylboronic acid (PBA) have emerged as a key strategy for enhancing therapeutic efficacy by active targeting of tumor and improving drug loading capacity. Herein, we have developed a PBA-modified chitosan-based (PBA-CS) semi-interpenetrating polymer network (semi-IPN) nanoparticles (NPs) of 4-carboxy-phenylboronic acid-conjugated chitosan-poly-(1-vinylimidazole) (PBA-CS-PVIm) and 4-carboxy-phenylboronic acid-conjugated chitosan-poly-(methacrylic acid) (PBA-CS-PMAA) via free radical polymerization of 1-vinyl imidazole (VIm) and methacrylic acid (MAA), with high drug loading capacity of doxorubicin (Dox). The synthesized semi-IPN NPs were characterized using Fourier transform infrared spectroscopy (ATR-FTIR), transmi2026-01-01T00:00:00Z2026 Feb2026-07-16T17:59:13.506Z2026-07-09T11:10:18.763ZS-EPMC129176454172661610.1021/acsomega.5c04836