{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(6)"],"submitter":["Podjed Rihtarsic N"],"pubmed_abstract":["Furosemide, a sulfonamide-based diuretic, may also be of interest as a ligand capable of binding to metal ions. Our studies of zinc-(II) coordination chemistry with furosemide in organic solvents resulted in a crystalline precipitate. Initial characterization was challenging because single crystals were of insufficient quality for an unambiguous structural determination. X-ray analysis confirmed a four-coordinate zinc-(II) complex with two deprotonated furosemides (fur<sup>-</sup>) bound in a monodentate manner and two simple monodentate ligands. Complementary techniques, i.e., infrared spectroscopy, NMR spectroscopy, and thermal analysis, revealed their identity as ammonia, generated <i>in situ</i> from acetonitrile hydrolysis. The composition of the product is thus [Zn-(fur)<sub>2</sub>("],"journal":["ACS omega"],"pagination":["10614-10619"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12917693"],"repository":["biostudies-literature"],"pubmed_title":["By Chance, Not Design: A New Furosemide Derivative From Zinc(II) Complex Studies."],"pmcid":["PMC12917693"],"pubmed_authors":["Modec B","Podjed Rihtarsic N","Cerc Korosec R"],"additional_accession":[]},"is_claimable":false,"name":"By Chance, Not Design: A New Furosemide Derivative From Zinc(II) Complex Studies.","description":"Furosemide, a sulfonamide-based diuretic, may also be of interest as a ligand capable of binding to metal ions. Our studies of zinc-(II) coordination chemistry with furosemide in organic solvents resulted in a crystalline precipitate. Initial characterization was challenging because single crystals were of insufficient quality for an unambiguous structural determination. X-ray analysis confirmed a four-coordinate zinc-(II) complex with two deprotonated furosemides (fur<sup>-</sup>) bound in a monodentate manner and two simple monodentate ligands. Complementary techniques, i.e., infrared spectroscopy, NMR spectroscopy, and thermal analysis, revealed their identity as ammonia, generated <i>in situ</i> from acetonitrile hydrolysis. The composition of the product is thus [Zn-(fur)<sub>2</sub>(","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T18:00:38.046Z","creation":"2026-07-09T11:10:35.792Z"},"accession":"S-EPMC12917693","cross_references":{"pubmed":["41726619"],"doi":["10.1021/acsomega.5c12211"]}}