biostudies-literatureUnknown11(6)Podjed Rihtarsic NFurosemide, a sulfonamide-based diuretic, may also be of interest as a ligand capable of binding to metal ions. Our studies of zinc-(II) coordination chemistry with furosemide in organic solvents resulted in a crystalline precipitate. Initial characterization was challenging because single crystals were of insufficient quality for an unambiguous structural determination. X-ray analysis confirmed a four-coordinate zinc-(II) complex with two deprotonated furosemides (fur^-) bound in a monodentate manner and two simple monodentate ligands. Complementary techniques, i.e., infrared spectroscopy, NMR spectroscopy, and thermal analysis, revealed their identity as ammonia, generated <i>in situ</i> from acetonitrile hydrolysis. The composition of the product is thus [Zn-(fur)₂(ACS omega10614-10619https://www.ebi.ac.uk/biostudies/studies/S-EPMC12917693biostudies-literatureBy Chance, Not Design: A New Furosemide Derivative From Zinc(II) Complex Studies.PMC12917693Modec BPodjed Rihtarsic NCerc Korosec RfalseBy Chance, Not Design: A New Furosemide Derivative From Zinc(II) Complex Studies.Furosemide, a sulfonamide-based diuretic, may also be of interest as a ligand capable of binding to metal ions. Our studies of zinc-(II) coordination chemistry with furosemide in organic solvents resulted in a crystalline precipitate. Initial characterization was challenging because single crystals were of insufficient quality for an unambiguous structural determination. X-ray analysis confirmed a four-coordinate zinc-(II) complex with two deprotonated furosemides (fur^-) bound in a monodentate manner and two simple monodentate ligands. Complementary techniques, i.e., infrared spectroscopy, NMR spectroscopy, and thermal analysis, revealed their identity as ammonia, generated <i>in situ</i> from acetonitrile hydrolysis. The composition of the product is thus [Zn-(fur)₂(2026-01-01T00:00:00Z2026 Feb2026-07-16T18:00:38.046Z2026-07-09T11:10:35.792ZS-EPMC129176934172661910.1021/acsomega.5c12211