biostudies-literatureXu HHongyuan XuChengning Yang135https://www.ebi.ac.uk/biostudies/studies/S-EPMC12918245biostudies-literatureUnknown26(1)<h4>Objective</h4>Although gastric secretory dysfunction is common in H.pylori-associated gastropathy, the precise mechanisms underlying these functional alterations across different H.pylori antibody subtypes remain incompletely elucidated. This cross-sectional clinical observational study aimed to systematically investigate the associations between specific H.pylori antibody subtype infection status and multiple gastric functional parameters, thereby elucidating potential differences in their impact on gastric secretory function.<h4>Methods</h4>A total of 2,618 patients were included in this analysis. Serum levels of pepsinogen I (PGI), pepsinogen II (PGII), the PGI/PGII ratio (PGR), gastrin-17 (G-17), and H.pylori antibody subtypes were measured. A cross-sectional study design was emploBMC gastroenterologyDifferential impacts of Helicobacter pylori antibody typing on gastric secretory function: a cross-sectional study based on serum biomarkers.PMC12918245No.82460915No.B2024316Yang YLiang XZhong GChen XXu HYang CZhu CZhao XfalseDifferential impacts of Helicobacter pylori antibody typing on gastric secretory function: a cross-sectional study based on serum biomarkers.<h4>Objective</h4>Although gastric secretory dysfunction is common in H.pylori-associated gastropathy, the precise mechanisms underlying these functional alterations across different H.pylori antibody subtypes remain incompletely elucidated. This cross-sectional clinical observational study aimed to systematically investigate the associations between specific H.pylori antibody subtype infection status and multiple gastric functional parameters, thereby elucidating potential differences in their impact on gastric secretory function.<h4>Methods</h4>A total of 2,618 patients were included in this analysis. Serum levels of pepsinogen I (PGI), pepsinogen II (PGII), the PGI/PGII ratio (PGR), gastrin-17 (G-17), and H.pylori antibody subtypes were measured. A cross-sectional study design was emplo2026-01-01T00:00:00Z2026 Jan2026-07-16T07:51:49.675Z2026-07-09T10:46:13.227ZS-EPMC129182454158834910.1186/s12876-026-04611-0