biostudies-literatureZhang LGuangdong Medical Science FoundationNational Natural Science Foundation of ChinaNatural Science Foundation of Guangdong Provincethe Natural Science Foundation of Guangdong Province178https://www.ebi.ac.uk/biostudies/studies/S-EPMC12918463biostudies-literatureUnknown24(1)Photodynamic therapy (PDT) is an effective adjunct treatment for oral squamous cell carcinoma (OSCC). Enhancing photosensitizer targeting and inducing effective cytotoxic T-cell responses through photoimmunotherapy have become key strategies to improve PDT efficacy. Migrasomes, as vesicular structures assembled by TSPAN4 and cholesterol microdomains, are implicated in immune escape and are emerging as sensitization targets for PDT. Here, we report a biomimetic nanoplatform, MOF-919@CCM, that combines enhanced tumor-cell membrane adhesion with light-controlled cholesterol degradation. Cloaking with a homologous cancer-cell membrane (CCM) imparts specific adhesion to tumor cells and improves targeted delivery of the photosensitizer. Moreover, the transition-metal nodes of MOF-919 exhibit perJournal of nanobiotechnologyMigrasomes constrained by a homologous-targeting photodynamic nanoplatform: enhancing intratumoral CD8<sup>+</sup> T-cell-associated antitumor immunity in oral squamous cell carcinoma.PMC12918463823732552024A15150129188250123082571048557A20252382025A1515010769Wu JHe YShi FZhao WJia WYu DZhang LGao HChen XLi RLi KPan KfalseMigrasomes constrained by a homologous-targeting photodynamic nanoplatform: enhancing intratumoral CD8<sup>+</sup> T-cell-associated antitumor immunity in oral squamous cell carcinoma.Photodynamic therapy (PDT) is an effective adjunct treatment for oral squamous cell carcinoma (OSCC). Enhancing photosensitizer targeting and inducing effective cytotoxic T-cell responses through photoimmunotherapy have become key strategies to improve PDT efficacy. Migrasomes, as vesicular structures assembled by TSPAN4 and cholesterol microdomains, are implicated in immune escape and are emerging as sensitization targets for PDT. Here, we report a biomimetic nanoplatform, MOF-919@CCM, that combines enhanced tumor-cell membrane adhesion with light-controlled cholesterol degradation. Cloaking with a homologous cancer-cell membrane (CCM) imparts specific adhesion to tumor cells and improves targeted delivery of the photosensitizer. Moreover, the transition-metal nodes of MOF-919 exhibit per2026-01-01T00:00:00Z2026 Jan2026-07-16T10:03:13.361Z2026-07-09T10:48:19.373ZS-EPMC129184634158839810.1186/s12951-026-04037-6