{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Sun H"],"pubmed_abstract":["Our previous research identified that an oral mPEG-b-PCL polymeric micelle (PM) maintained satisfactory integrity but exhibited limited transcytosis efficiency. To enhance transcytosis and enable ROS-responsive release, we developed a series of hybrid PMs by blending a synthesized L-carnitine-grafted, thioketal-linked LC-PEG<sub>5k</sub>-TK-PCL<sub>7k</sub> polymer with mPEG<sub>5k</sub>-PCL<sub>7k</sub>. These hybrid PMs, similar in particle size (120 nm) and drug loading (10%) to the PM composed of pure mPEG<sub>5k</sub>-PCL<sub>7k</sub> (5-7E), retained good stability in SGF and SIF. However, the hybrid PM with a 40% LC-PEG<sub>5k</sub>-TK-PCL<sub>7k</sub> proportion showed reduced integrity and penetration in mucus layer. In Caco-2/E12 (7:3) cells, the hybrid PM with a 20% LC-PEG<sub>5"],"journal":["Journal of nanobiotechnology"],"pagination":["182"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12918599"],"repository":["biostudies-literature"],"pubmed_title":["OCTN2-targeted and ROS-responsive hybrid polymeric micelles for oral delivery of docetaxel."],"pmcid":["PMC12918599"],"pubmed_authors":["Bi X","Sui B","Jin X","Liu B","Gou J","Sun H","Song J"],"additional_accession":[]},"is_claimable":false,"name":"OCTN2-targeted and ROS-responsive hybrid polymeric micelles for oral delivery of docetaxel.","description":"Our previous research identified that an oral mPEG-b-PCL polymeric micelle (PM) maintained satisfactory integrity but exhibited limited transcytosis efficiency. To enhance transcytosis and enable ROS-responsive release, we developed a series of hybrid PMs by blending a synthesized L-carnitine-grafted, thioketal-linked LC-PEG<sub>5k</sub>-TK-PCL<sub>7k</sub> polymer with mPEG<sub>5k</sub>-PCL<sub>7k</sub>. These hybrid PMs, similar in particle size (120 nm) and drug loading (10%) to the PM composed of pure mPEG<sub>5k</sub>-PCL<sub>7k</sub> (5-7E), retained good stability in SGF and SIF. However, the hybrid PM with a 40% LC-PEG<sub>5k</sub>-TK-PCL<sub>7k</sub> proportion showed reduced integrity and penetration in mucus layer. In Caco-2/E12 (7:3) cells, the hybrid PM with a 20% LC-PEG<sub>5","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T10:06:03.547Z","creation":"2026-07-09T10:48:53.49Z"},"accession":"S-EPMC12918599","cross_references":{"pubmed":["41593744"],"doi":["10.1186/s12951-026-04067-0"]}}